Nonlinear compartmental model of F-18-choline

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Nonlinear compartmental model of F-18-choline. / Tavola, Federico; Janzen, Tilman; Giussani, Augusto; Facchinetti, Danya; Veronese, Ivan; Uusijärvi, Helena; Mattsson, Sören; Hoeschen, Christoph; Cantone, Marie Claire.

I: Nuclear Medicine and Biology, Vol. 39, Nr. 2, 2012, s. 261-268.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Tavola, F, Janzen, T, Giussani, A, Facchinetti, D, Veronese, I, Uusijärvi, H, Mattsson, S, Hoeschen, C & Cantone, MC 2012, 'Nonlinear compartmental model of F-18-choline', Nuclear Medicine and Biology, vol. 39, nr. 2, s. 261-268. https://doi.org/10.1016/j.nucmedbio.2011.09.002

APA

Tavola, F., Janzen, T., Giussani, A., Facchinetti, D., Veronese, I., Uusijärvi, H., ... Cantone, M. C. (2012). Nonlinear compartmental model of F-18-choline. Nuclear Medicine and Biology, 39(2), 261-268. https://doi.org/10.1016/j.nucmedbio.2011.09.002

CBE

Tavola F, Janzen T, Giussani A, Facchinetti D, Veronese I, Uusijärvi H, Mattsson S, Hoeschen C, Cantone MC. 2012. Nonlinear compartmental model of F-18-choline. Nuclear Medicine and Biology. 39(2):261-268. https://doi.org/10.1016/j.nucmedbio.2011.09.002

MLA

Vancouver

Tavola F, Janzen T, Giussani A, Facchinetti D, Veronese I, Uusijärvi H et al. Nonlinear compartmental model of F-18-choline. Nuclear Medicine and Biology. 2012;39(2):261-268. https://doi.org/10.1016/j.nucmedbio.2011.09.002

Author

Tavola, Federico ; Janzen, Tilman ; Giussani, Augusto ; Facchinetti, Danya ; Veronese, Ivan ; Uusijärvi, Helena ; Mattsson, Sören ; Hoeschen, Christoph ; Cantone, Marie Claire. / Nonlinear compartmental model of F-18-choline. I: Nuclear Medicine and Biology. 2012 ; Vol. 39, Nr. 2. s. 261-268.

RIS

TY - JOUR

T1 - Nonlinear compartmental model of F-18-choline

AU - Tavola, Federico

AU - Janzen, Tilman

AU - Giussani, Augusto

AU - Facchinetti, Danya

AU - Veronese, Ivan

AU - Uusijärvi, Helena

AU - Mattsson, Sören

AU - Hoeschen, Christoph

AU - Cantone, Marie Claire

PY - 2012

Y1 - 2012

N2 - Introduction: This work develops a compartmental model of F-18-choline in order to evaluate its biokinetics and so to describe the temporal variation of the radiopharmaceuticals' uptake in and clearance from organs and tissues. Methods: Ten patients were considered in this study. A commercially available tool for compartmental analysis (SAAM II) was used to model the values of activity concentrations in organs and tissues obtained from PET images or from measurements of collected blood and urine samples. Results: A linear compartmental model of the biokinetics of the radiopharmaceutical was initially developed. It features a central compartment (blood) exchanging with organs. The structure describes explicitly liver, kidneys, spleen, blood and urinary excretion. The linear model tended to overestimate systematically the activity in the liver and in the kidney compartments in the first 20 min post-administration. A nonlinear process of kinetic saturation was considered, according to the typical Michaelis-Menten kinetics. Therefore nonlinear equations were added to describe the flux of 18F-choline from blood to liver and from blood to kidneys. The nonlinear model showed a tendency for improvement in the description of the activity in liver and kidneys, but not for the urine. Conclusions: The simple linear model presented is not able to properly describe the biokinetics of 18F-choline as measured in prostatic cancer patients. The introduction of nonlinear kinetics, although based on physiologically plausible assumptions, resulted in nonsignificant improvements of the model predictive power. (C) 2012 Elsevier Inc. All rights reserved.

AB - Introduction: This work develops a compartmental model of F-18-choline in order to evaluate its biokinetics and so to describe the temporal variation of the radiopharmaceuticals' uptake in and clearance from organs and tissues. Methods: Ten patients were considered in this study. A commercially available tool for compartmental analysis (SAAM II) was used to model the values of activity concentrations in organs and tissues obtained from PET images or from measurements of collected blood and urine samples. Results: A linear compartmental model of the biokinetics of the radiopharmaceutical was initially developed. It features a central compartment (blood) exchanging with organs. The structure describes explicitly liver, kidneys, spleen, blood and urinary excretion. The linear model tended to overestimate systematically the activity in the liver and in the kidney compartments in the first 20 min post-administration. A nonlinear process of kinetic saturation was considered, according to the typical Michaelis-Menten kinetics. Therefore nonlinear equations were added to describe the flux of 18F-choline from blood to liver and from blood to kidneys. The nonlinear model showed a tendency for improvement in the description of the activity in liver and kidneys, but not for the urine. Conclusions: The simple linear model presented is not able to properly describe the biokinetics of 18F-choline as measured in prostatic cancer patients. The introduction of nonlinear kinetics, although based on physiologically plausible assumptions, resulted in nonsignificant improvements of the model predictive power. (C) 2012 Elsevier Inc. All rights reserved.

KW - F-18-Choline

KW - PET

KW - Nonlinear model

KW - Kinetic saturation

KW - Prostate

KW - carcinoma

U2 - 10.1016/j.nucmedbio.2011.09.002

DO - 10.1016/j.nucmedbio.2011.09.002

M3 - Article

VL - 39

SP - 261

EP - 268

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

SN - 1872-9614

IS - 2

ER -