Nonmotor fluctuations in Parkinson disease: Severity and correlation with motor complications.

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Nonmotor fluctuations in Parkinson disease: Severity and correlation with motor complications. / Storch, Alexander; Schneider, Christine B; Wolz, Martin; Stürwald, Yannic; Nebe, Angelika; Odin, Per; Mahler, Andreas; Fuchs, Gerd; Jost, Wolfgang H; Chaudhuri, K Ray; Koch, Rainer; Reichmann, Heinz; Ebersbach, Georg.

I: Neurology, Vol. 80, Nr. 9, 2013, s. 800-809.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Storch, A, Schneider, CB, Wolz, M, Stürwald, Y, Nebe, A, Odin, P, Mahler, A, Fuchs, G, Jost, WH, Chaudhuri, KR, Koch, R, Reichmann, H & Ebersbach, G 2013, 'Nonmotor fluctuations in Parkinson disease: Severity and correlation with motor complications.', Neurology, vol. 80, nr. 9, s. 800-809. https://doi.org/10.1212/WNL.0b013e318285c0ed

APA

Storch, A., Schneider, C. B., Wolz, M., Stürwald, Y., Nebe, A., Odin, P., ... Ebersbach, G. (2013). Nonmotor fluctuations in Parkinson disease: Severity and correlation with motor complications. Neurology, 80(9), 800-809. https://doi.org/10.1212/WNL.0b013e318285c0ed

CBE

Storch A, Schneider CB, Wolz M, Stürwald Y, Nebe A, Odin P, Mahler A, Fuchs G, Jost WH, Chaudhuri KR, Koch R, Reichmann H, Ebersbach G. 2013. Nonmotor fluctuations in Parkinson disease: Severity and correlation with motor complications. Neurology. 80(9):800-809. https://doi.org/10.1212/WNL.0b013e318285c0ed

MLA

Vancouver

Author

Storch, Alexander ; Schneider, Christine B ; Wolz, Martin ; Stürwald, Yannic ; Nebe, Angelika ; Odin, Per ; Mahler, Andreas ; Fuchs, Gerd ; Jost, Wolfgang H ; Chaudhuri, K Ray ; Koch, Rainer ; Reichmann, Heinz ; Ebersbach, Georg. / Nonmotor fluctuations in Parkinson disease: Severity and correlation with motor complications. I: Neurology. 2013 ; Vol. 80, Nr. 9. s. 800-809.

RIS

TY - JOUR

T1 - Nonmotor fluctuations in Parkinson disease: Severity and correlation with motor complications.

AU - Storch, Alexander

AU - Schneider, Christine B

AU - Wolz, Martin

AU - Stürwald, Yannic

AU - Nebe, Angelika

AU - Odin, Per

AU - Mahler, Andreas

AU - Fuchs, Gerd

AU - Jost, Wolfgang H

AU - Chaudhuri, K Ray

AU - Koch, Rainer

AU - Reichmann, Heinz

AU - Ebersbach, Georg

PY - 2013

Y1 - 2013

N2 - OBJECTIVE: To evaluate frequency, severity, and correlation of nonmotor symptoms (NMS) with motor complications in fluctuating Parkinson disease (PD). METHODS: The Multicenter NonMotor Fluctuations in PD cross-sectional study used clinical examination of 10 NMS (dysphagia, anxiety, depression, fatigue, excessive sweating, inner restlessness, pain, concentration/attention, dizziness, bladder urgency) quantified using a visual analogue scale (VAS) in motor-defined on (NMS(On)) and off state (NMS(Off)) combined with motor assessments and self-ratings at home in 100 patients with advanced PD. RESULTS: All NMS except dysphagia, excessive sweating, and bladder urgency fluctuated in conjunction to motor fluctuations with more frequent and severe symptoms in off compared to on state. The proportions of patients experiencing autonomic/sensory NMS in both motor states were similar to those with these NMS exclusively in off state (ratios 0.4-1.3), while for mental/psychic NMS the proportions with exclusive manifestation in off state were higher (ratios 1.8-3.1). Demographic and clinical characteristics correlated neither with NMS frequency patterns and severities nor with ΔNMS(On/Off) severities (defined as the differences of VAS scores between on and off). Severities of NMS(on), NMS(Off), and ΔNMS(On/Off) did not correlate with motor function. Presence of anxiety, depression, fatigue, and pain had negative impact on health-related quality of life (HRQOL) measured by Parkinson's Disease Questionnaire-8 scoring independent of their occurrence with respect to motor state. Fluctuations of these NMS but not of fatigue deteriorated HRQOL. CONCLUSION: Patterns of NMS fluctuations are heterogeneous and complex, but psychic NMS fluctuate more frequently and severely. Demographic parameters and motor function do not correlate with NMS or nonmotor fluctuation severities in fluctuating PD.

AB - OBJECTIVE: To evaluate frequency, severity, and correlation of nonmotor symptoms (NMS) with motor complications in fluctuating Parkinson disease (PD). METHODS: The Multicenter NonMotor Fluctuations in PD cross-sectional study used clinical examination of 10 NMS (dysphagia, anxiety, depression, fatigue, excessive sweating, inner restlessness, pain, concentration/attention, dizziness, bladder urgency) quantified using a visual analogue scale (VAS) in motor-defined on (NMS(On)) and off state (NMS(Off)) combined with motor assessments and self-ratings at home in 100 patients with advanced PD. RESULTS: All NMS except dysphagia, excessive sweating, and bladder urgency fluctuated in conjunction to motor fluctuations with more frequent and severe symptoms in off compared to on state. The proportions of patients experiencing autonomic/sensory NMS in both motor states were similar to those with these NMS exclusively in off state (ratios 0.4-1.3), while for mental/psychic NMS the proportions with exclusive manifestation in off state were higher (ratios 1.8-3.1). Demographic and clinical characteristics correlated neither with NMS frequency patterns and severities nor with ΔNMS(On/Off) severities (defined as the differences of VAS scores between on and off). Severities of NMS(on), NMS(Off), and ΔNMS(On/Off) did not correlate with motor function. Presence of anxiety, depression, fatigue, and pain had negative impact on health-related quality of life (HRQOL) measured by Parkinson's Disease Questionnaire-8 scoring independent of their occurrence with respect to motor state. Fluctuations of these NMS but not of fatigue deteriorated HRQOL. CONCLUSION: Patterns of NMS fluctuations are heterogeneous and complex, but psychic NMS fluctuate more frequently and severely. Demographic parameters and motor function do not correlate with NMS or nonmotor fluctuation severities in fluctuating PD.

U2 - 10.1212/WNL.0b013e318285c0ed

DO - 10.1212/WNL.0b013e318285c0ed

M3 - Article

VL - 80

SP - 800

EP - 809

JO - Neurology

JF - Neurology

SN - 1526-632X

IS - 9

ER -