Nonsense Mutations in the Shelterin Complex Genes ACD and TERF2IP in Familial Melanoma.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The shelterin complex protects chromosomal ends by regulating how the telomerase complex interacts with telomeres. Following the recent finding in familial melanoma of inactivating germline mutations in POT1, encoding a member of the shelterin complex, we searched for mutations in the other five components of the shelterin complex in melanoma families.

Detaljer

Författare
  • Lauren G Aoude
  • Antonia L Pritchard
  • Carla Daniela Robles-Espinoza
  • Karin Wadt
  • Mark Harland
  • Jiyeon Choi
  • Michael Gartside
  • Víctor Quesada
  • Peter Johansson
  • Jane M Palmer
  • Andrew J Ramsay
  • Xijun Zhang
  • Kristine Jones
  • Judith Symmons
  • Elizabeth A Holland
  • Helen Schmid
  • Vanessa Bonazzi
  • Susan Woods
  • Ken Dutton-Regester
  • Mitchell S Stark
  • Helen Snowden
  • Remco van Doorn
  • Grant W Montgomery
  • Nicholas G Martin
  • Thomas M Keane
  • Carlos López-Otín
  • Anne-Marie Gerdes
  • Nelleke A Gruis
  • Jeffrey M Trent
  • D Timothy Bishop
  • Graham J Mann
  • Julia A Newton-Bishop
  • Kevin M Brown
  • David J Adams
  • Nicholas K Hayward
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
Originalspråkengelska
Sidor (från-till)dju408
TidskriftJournal of the National Cancer Institute
Volym107
Utgåva nummer2
StatusPublished - 2015
PublikationskategoriForskning
Peer review utfördJa