Novel aspects of vitamin C: how important is glypican-1 recycling?

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

The reduced form of vitamin C, ascorbic acid, is well known for its function as an antioxidant and as a protective agent against scurvy. However, many recent studies indicate other functions for vitamin C in mammalian cells. Novel findings provide possible explanations for observed beneficial effects of a high intake of vitamin C on cell growth, gene transcription, host resistance to infection, uptake of polyamines and clearance of misfolded proteins. Vitamin C exerts its effects indirectly via hypoxia-inducible factor, nitric oxide synthase and the heparan sulfate proteoglycan glypican-1, which is deglycanated in a vitamin C- and copper-dependent reaction.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cell- och molekylärbiologi
Originalspråkengelska
Sidor (från-till)143-149
TidskriftTrends in Molecular Medicine
Volym13
Utgivningsnummer4
StatusPublished - 2007
PublikationskategoriForskning
Peer review utfördJa

Nedladdningar

Ingen tillgänglig data