OARSI/OMERACT Initiative to Define States of Severity and Indication for Joint Replacement in Hip and Knee Osteoarthritis. An OMERACT 10 Special Interest Group

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

OARSI/OMERACT Initiative to Define States of Severity and Indication for Joint Replacement in Hip and Knee Osteoarthritis. An OMERACT 10 Special Interest Group. / Gossec, Laure; Paternotte, Simon; Bingham, Clifton O., III; Clegg, Daniel O.; Coste, Philippe; Conaghan, Philip G.; Davis, Aileen M.; Giacovelli, Giampaolo; Gunther, Klaus-Peter; Hawker, Gillian; Hochberg, Marc C.; Jordan, Joanne M.; Katz, Jeffrey N.; Kloppenburg, Margreet; Lanzarotti, Arturo; Lim, Keith; Lohmander, Stefan; Mahomed, Nizar N.; Maillefert, Jean Francis; Manno, Rebecca L.; March, Lyn M.; Mazzuca, Steven A.; Pavelka, Karel; Punzi, Leonardo; Roos, Ewa M.; Rovati, Lucio C.; Shi, Helen; Singh, Jasvinder A.; Suarez-Almazor, Maria E.; Tajana-Messi, Eleonora; Dougados, Maxime.

I: Journal of Rheumatology, Vol. 38, Nr. 8, 2011, s. 1765-1769.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Gossec, L, Paternotte, S, Bingham, COIII, Clegg, DO, Coste, P, Conaghan, PG, Davis, AM, Giacovelli, G, Gunther, K-P, Hawker, G, Hochberg, MC, Jordan, JM, Katz, JN, Kloppenburg, M, Lanzarotti, A, Lim, K, Lohmander, S, Mahomed, NN, Maillefert, JF, Manno, RL, March, LM, Mazzuca, SA, Pavelka, K, Punzi, L, Roos, EM, Rovati, LC, Shi, H, Singh, JA, Suarez-Almazor, ME, Tajana-Messi, E & Dougados, M 2011, 'OARSI/OMERACT Initiative to Define States of Severity and Indication for Joint Replacement in Hip and Knee Osteoarthritis. An OMERACT 10 Special Interest Group', Journal of Rheumatology, vol. 38, nr. 8, s. 1765-1769. https://doi.org/10.3899/jrheum.110403

APA

Gossec, L., Paternotte, S., Bingham, C. O. . III., Clegg, D. O., Coste, P., Conaghan, P. G., Davis, A. M., Giacovelli, G., Gunther, K-P., Hawker, G., Hochberg, M. C., Jordan, J. M., Katz, J. N., Kloppenburg, M., Lanzarotti, A., Lim, K., Lohmander, S., Mahomed, N. N., Maillefert, J. F., ... Dougados, M. (2011). OARSI/OMERACT Initiative to Define States of Severity and Indication for Joint Replacement in Hip and Knee Osteoarthritis. An OMERACT 10 Special Interest Group. Journal of Rheumatology, 38(8), 1765-1769. https://doi.org/10.3899/jrheum.110403

CBE

Gossec L, Paternotte S, Bingham COIII, Clegg DO, Coste P, Conaghan PG, Davis AM, Giacovelli G, Gunther K-P, Hawker G, Hochberg MC, Jordan JM, Katz JN, Kloppenburg M, Lanzarotti A, Lim K, Lohmander S, Mahomed NN, Maillefert JF, Manno RL, March LM, Mazzuca SA, Pavelka K, Punzi L, Roos EM, Rovati LC, Shi H, Singh JA, Suarez-Almazor ME, Tajana-Messi E, Dougados M. 2011. OARSI/OMERACT Initiative to Define States of Severity and Indication for Joint Replacement in Hip and Knee Osteoarthritis. An OMERACT 10 Special Interest Group. Journal of Rheumatology. 38(8):1765-1769. https://doi.org/10.3899/jrheum.110403

MLA

Vancouver

Author

Gossec, Laure ; Paternotte, Simon ; Bingham, Clifton O., III ; Clegg, Daniel O. ; Coste, Philippe ; Conaghan, Philip G. ; Davis, Aileen M. ; Giacovelli, Giampaolo ; Gunther, Klaus-Peter ; Hawker, Gillian ; Hochberg, Marc C. ; Jordan, Joanne M. ; Katz, Jeffrey N. ; Kloppenburg, Margreet ; Lanzarotti, Arturo ; Lim, Keith ; Lohmander, Stefan ; Mahomed, Nizar N. ; Maillefert, Jean Francis ; Manno, Rebecca L. ; March, Lyn M. ; Mazzuca, Steven A. ; Pavelka, Karel ; Punzi, Leonardo ; Roos, Ewa M. ; Rovati, Lucio C. ; Shi, Helen ; Singh, Jasvinder A. ; Suarez-Almazor, Maria E. ; Tajana-Messi, Eleonora ; Dougados, Maxime. / OARSI/OMERACT Initiative to Define States of Severity and Indication for Joint Replacement in Hip and Knee Osteoarthritis. An OMERACT 10 Special Interest Group. I: Journal of Rheumatology. 2011 ; Vol. 38, Nr. 8. s. 1765-1769.

RIS

TY - JOUR

T1 - OARSI/OMERACT Initiative to Define States of Severity and Indication for Joint Replacement in Hip and Knee Osteoarthritis. An OMERACT 10 Special Interest Group

AU - Gossec, Laure

AU - Paternotte, Simon

AU - Bingham, Clifton O., III

AU - Clegg, Daniel O.

AU - Coste, Philippe

AU - Conaghan, Philip G.

AU - Davis, Aileen M.

AU - Giacovelli, Giampaolo

AU - Gunther, Klaus-Peter

AU - Hawker, Gillian

AU - Hochberg, Marc C.

AU - Jordan, Joanne M.

AU - Katz, Jeffrey N.

AU - Kloppenburg, Margreet

AU - Lanzarotti, Arturo

AU - Lim, Keith

AU - Lohmander, Stefan

AU - Mahomed, Nizar N.

AU - Maillefert, Jean Francis

AU - Manno, Rebecca L.

AU - March, Lyn M.

AU - Mazzuca, Steven A.

AU - Pavelka, Karel

AU - Punzi, Leonardo

AU - Roos, Ewa M.

AU - Rovati, Lucio C.

AU - Shi, Helen

AU - Singh, Jasvinder A.

AU - Suarez-Almazor, Maria E.

AU - Tajana-Messi, Eleonora

AU - Dougados, Maxime

PY - 2011

Y1 - 2011

N2 - Objective. To define pain and physical function cutpoints that would, coupled with structural severity, define a surrogate measure of "need for joint replacement surgery," for use as an outcome measure for potential structure-modifying interventions for osteoarthritis (OA). Methods. New scores were developed for pain and physical function in knee and hip OA. A cross-sectional international study in 1909 patients was conducted to define data-driven cutpoints corresponding to the orthopedic surgeons' indication for joint replacement. A post hoc analysis of 8 randomized clinical trials (1379 patients) evaluated the prevalence and validity of cutpoints, among patients with symptomatic hip/knee OA. Results. In the international cross-sectional study, there was substantial overlap in symptom levels between patients with and patients without indication for joint replacement; indeed, it was not possible to determine cutpoints for pain and function defining this indication. The post hoc analysis of trial data showed that the prevalence of cases that combined radiological progression, high level of pain, and high degree of function impairment was low (2%-12%). The most discriminatory cutpoint to define an indication for joint replacement was found to be [pain (0-100) + physical function (0-100) > 80]. Conclusion. These results do not support a specific level of pain or function that defines an indication for joint replacement. However, a tentative cutpoint for pain and physical function levels is proposed for further evaluation. Potentially, this symptom level, coupled with radiographic progression, could be used to define "nonresponders" to disease-modifying drugs in OA clinical trials. (J Rheumatol 2011;38:1765-9; doi:10.3899/jrheum.110403)

AB - Objective. To define pain and physical function cutpoints that would, coupled with structural severity, define a surrogate measure of "need for joint replacement surgery," for use as an outcome measure for potential structure-modifying interventions for osteoarthritis (OA). Methods. New scores were developed for pain and physical function in knee and hip OA. A cross-sectional international study in 1909 patients was conducted to define data-driven cutpoints corresponding to the orthopedic surgeons' indication for joint replacement. A post hoc analysis of 8 randomized clinical trials (1379 patients) evaluated the prevalence and validity of cutpoints, among patients with symptomatic hip/knee OA. Results. In the international cross-sectional study, there was substantial overlap in symptom levels between patients with and patients without indication for joint replacement; indeed, it was not possible to determine cutpoints for pain and function defining this indication. The post hoc analysis of trial data showed that the prevalence of cases that combined radiological progression, high level of pain, and high degree of function impairment was low (2%-12%). The most discriminatory cutpoint to define an indication for joint replacement was found to be [pain (0-100) + physical function (0-100) > 80]. Conclusion. These results do not support a specific level of pain or function that defines an indication for joint replacement. However, a tentative cutpoint for pain and physical function levels is proposed for further evaluation. Potentially, this symptom level, coupled with radiographic progression, could be used to define "nonresponders" to disease-modifying drugs in OA clinical trials. (J Rheumatol 2011;38:1765-9; doi:10.3899/jrheum.110403)

KW - OSTEOARTHRITIS

KW - SEVERITY

KW - PAIN

KW - FUNCTION

KW - STRUCTURE OUTCOME MEASURE

U2 - 10.3899/jrheum.110403

DO - 10.3899/jrheum.110403

M3 - Article

C2 - 21807799

VL - 38

SP - 1765

EP - 1769

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 8

ER -