Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins

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Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins. / Bolton, Derek; Rijsdijk, Fruhling; O'Connor, Thomas; Perrin, Sean; Eley, Thalia.

I: Psychological Medicine, Vol. 37, Nr. 1, 2006, s. 39-48.

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Bolton, Derek ; Rijsdijk, Fruhling ; O'Connor, Thomas ; Perrin, Sean ; Eley, Thalia. / Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins. I: Psychological Medicine. 2006 ; Vol. 37, Nr. 1. s. 39-48.

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TY - JOUR

T1 - Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins

AU - Bolton, Derek

AU - Rijsdijk, Fruhling

AU - O'Connor, Thomas

AU - Perrin, Sean

AU - Eley, Thalia

PY - 2006

Y1 - 2006

N2 - Background. Previous reports of genetic influences on obsessive–compulsive disorder (OCD) symptoms have suggested moderate heritability. Family history studies of co-morbidity have found familial aggregation with tics, especially for early-onset OCD, and familial aggregation with anxiety disorders. Method. Heritability of OCD and familial aggregation of OCD, tics and anxiety disorders were investigated in a community sample of 6-year-old twins using a two-phase design in which 4662 twin pairs were sampled and 854 pairs were assessed in the second phase by maternal-informant diagnostic interview using DSM-IV criteria. Results. In the multivariate model combined additive genetic and common environmental effects were estimated as 47% for sub-threshold OCD, and the model was unable to distinguish these sources of familial aggregation. There were strong familial aggregations between sub-threshold OCD and tics and between sub-threshold OCD and other anxiety disorders (80% and 97% respectively), although again specific sources could not be distinguished. Conclusions. The findings are consistent with the hypothesis of a tic-related early-onset OCD phenotype, but also with the hypothesis of an anxiety-related early-onset OCD phenotype.

AB - Background. Previous reports of genetic influences on obsessive–compulsive disorder (OCD) symptoms have suggested moderate heritability. Family history studies of co-morbidity have found familial aggregation with tics, especially for early-onset OCD, and familial aggregation with anxiety disorders. Method. Heritability of OCD and familial aggregation of OCD, tics and anxiety disorders were investigated in a community sample of 6-year-old twins using a two-phase design in which 4662 twin pairs were sampled and 854 pairs were assessed in the second phase by maternal-informant diagnostic interview using DSM-IV criteria. Results. In the multivariate model combined additive genetic and common environmental effects were estimated as 47% for sub-threshold OCD, and the model was unable to distinguish these sources of familial aggregation. There were strong familial aggregations between sub-threshold OCD and tics and between sub-threshold OCD and other anxiety disorders (80% and 97% respectively), although again specific sources could not be distinguished. Conclusions. The findings are consistent with the hypothesis of a tic-related early-onset OCD phenotype, but also with the hypothesis of an anxiety-related early-onset OCD phenotype.

U2 - 10.1017/S0033291706008816

DO - 10.1017/S0033291706008816

M3 - Article

C2 - 16999878

VL - 37

SP - 39

EP - 48

JO - Psychological Medicine

JF - Psychological Medicine

SN - 1469-8978

IS - 1

ER -