Occupation and small bowel adenocarcinoma: A European case-control study

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Abstract

Objectives - Because of the rarity of small bowel adenocarcinoma (SBA), little is known about the aetiology of this disease. This study aimed to identify occupational clustering of cases SBA as a systematic approach to new hypotheses on the aetiology of this disease. Methods - A European multicentre case-control study was conducted in 1995-7, inclusive. Incident cases aged 35-69 years with SBA (n=168) were recruited before acceptance by a pathologist. Altogether 107 cases and 3915 controls were accepted, of which 79 cases, 579 colon cancer controls, and 2070 population controls were interviewed. Results - The strongest industrial risk factors for SBA taking account of 10 years' exposure lag were dry cleaning, manufacture of workwear, mixed farming (women), and manufacture of motor vehicles (men). A significantly increased risk of SBA (odds ratio (OR) and 95% confidence interval (95% CI)) was found among men employed as building caretakers, OR 6.7 (1.7 to 26.0) and women employed as housekeepers, OR 2.2 (1.1 to 4.9); general farm labourers, OR 4.7 (1.8 to 12.2); dockers, OR 2.9 (1.0 to 8.2); dry cleaners or launderers, OR 4.1 (1.2 to 13.6); and textile workers (sewers or embroiders), OR 2.6 (1.0 to 6.8). For the last four groups, together with welders OR 2.7 (1.1 to 6.6) (men) an exposure-response pattern was found when calculating the ORs for jobs held 1-5 years and >5 years, with never having held the job as reference. The ORs (95% CIs) for 1-5 years and >5 years were 4.3 (0.4 to 44.0) and 3.5 (0.9 to 13.7), 3.0 (0.3 to 26.2) and 4.3 (0.9 to 21.2), 4.6 (0.4 to 48.1) and 11.0 (2.0 to 60.4), 1.3 (0.2 to 11.0) and 5.8 (2.0 to 17.2), and 2.8 (0.3 to 23.8) and 4.6 (1.3 to 16.6), respectively, for each of these occupations. Among welders, people performing semi-automatic arc welding (MIG/MAG) were identified as a high risk group (OR 5.0 (1.3 to 19.6)). Conclusions - This explorative study suggests an increased occurrence of SBA in certain occupations, which needs further evaluation.

Detaljer

Författare
  • L. Kaerlev
  • G. Launoy
  • E. Merler
  • F. Merletti
  • M. M.M. Suarez-Varela
  • A. Stang
  • P. S. Teglbjaerg
  • S. Sabroe
  • H. A. Kolstad
  • W. Ahrens
  • M. Eriksson
  • A. L. Gonzalez
  • P. Guenel
  • L. Hardell
Externa organisationer
  • Aarhus University
  • Aarhus University Hospital
  • Cancer Research and Prevention Institute
  • Citta' della Salute e della Scienza Hospital-University of Turin
  • University of Valencia
  • University of Duisburg-Essen
  • Aalborg University Hospital
  • Leibniz Institute for Prevention Research and Epidemiology
  • Örebro University Hospital
  • Skåne University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi

Nyckelord

Originalspråkengelska
Sidor (från-till)760-766
TidskriftOccupational and environmental medicine
Volym57
Utgåva nummer11
StatusPublished - 2000 nov 7
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa