Occupational exposure to organic solvents and risk of male breast cancer: A European multicenter case-control study

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Objectives The etiology of male breast cancer (MBC) is largely unknown but a causal role of exposure to organic solvents has been suggested. Previous studies on occupational risk factors of breast cancer were often restricted to women who are frequently exposed to lower levels and at a lower frequency than men. We investigated the association between MBC and occupational exposure to petroleum and oxygenated and chlorinated solvents in a multicenter case-control study of rare cancers in Europe. Methods The study included 104 MBC cases and 1901 controls. Detailed lifetime work history was obtained during interviews, together with sociodemographic characteristics, medical history and lifestyle factors. Occupational exposures to solvents were estimated from a job-exposure matrix. Odds ratios (OR) and their 95% confidence intervals (CI) were calculated using unconditional logistic regression models. Results Lifetime cumulative exposure to trichloroethylene >23.9 ppm years was associated with an increased MBC risk, compared to non-exposure [OR (95% CI): 2.1 (1.2-4.0); P trend <0.01). This increase in risk persisted when only exposures that occurred ≥10 years before diagnosis were considered. In addition, a possible role for benzene and ethylene glycol in MBC risk was suggested, but no exposure-response trend was observed. Conclusions These findings add to the evidence of an increased risk of breast cancer among men professionally exposed to trichloroethylene and possibly to benzene or ethylene glycol. Further studies should be conducted in populations with high level of exposure to confirm our results.

Detaljer

Författare
  • Nasser Laouali
  • Corinne Pilorget
  • Diane Cyr
  • Monica Neri
  • Linda Kaerlev
  • Svend Sabroe
  • Giuseppe Gorini
  • Lorenzo Richiardi
  • Maria Morales-Suárez-Varela
  • Agustin Llopis-Gonzalez
  • Wolfgang Ahrens
  • Karl Heinz Jöckel
  • Noemia Afonso
  • Mikael Eriksson
  • Franco Merletti
  • Jørn Olsen
  • Elsebeth Lynge
  • Pascal Guénel
Externa organisationer
  • University of Paris-Sud
  • University of Southern Denmark
  • Odense University Hospital
  • Aarhus University
  • Cancer Research and Prevention Institute
  • University Hospital Essen
  • Skåne University Hospital
  • University of Copenhagen
  • Santé Publique France
  • Université Claude Bernard
  • National Institute for Health and Medical Research, France
  • University of Turin
  • University of Valencia
  • CIBER Epidemiology and Public Health (CIBERESP)
  • Leibniz Institute for Prevention Research and Epidemiology
  • Centro Hospitalar do Porto
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
  • Miljömedicin och yrkesmedicin

Nyckelord

Originalspråkengelska
Sidor (från-till)312-322
Antal sidor11
TidskriftScandinavian Journal of Work, Environment and Health
Volym44
Utgåva nummer3
StatusPublished - 2018 jan 1
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa