On the follicular pathway of percutaneous uptake of nanoparticles: Ion microscopy and autoradiography studies

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


We report on the visualization of the penetration of sunscreen formulations containing TiO2 nanoparticles (about 20 nm primary particle size) into hair follicles of both human and porcine skin using the complementary methods of ion microscopy (PIXE, RBS, STIM) and autoradiography. Particles were found as deep as approx. 400 pin in the follicle, obviously introduced mechanically rather than by a diffusive process. No particles were observed in vital tissue nor in sebaceous glands. (c) 2007 Elsevier B.V. All rights reserved.


  • J. Lekki
  • Z. Stachura
  • W. Dabros
  • J. Stachura
  • F. Menzel
  • T. Reinert
  • T. Butz
  • Jan Pallon
  • E. Gontier
  • M. D. Ynsa
  • P. Moretto
  • Z. Kertesz
  • Z. Szikszai
  • A. Z. Kiss
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Sidor (från-till)174-177
TidskriftNuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
Utgåva nummer1
StatusPublished - 2007
Peer review utfördJa