One evidence base; three stories: do opioids relieve chronic breathlessness?

Forskningsoutput: TidskriftsbidragLetter

Abstract

The efficacy of low-dose systemic opioids for chronic breathlessness was questioned by the recent Cochrane review by Barnes et al We examined the reasons for this conflicting finding and re-evaluated the efficacy of systemic opioids. Compared with previous meta-analyses, Barnes et al reported a smaller effect and lower precision, but did not account for matched data of crossover trials (11/12 included trials) and added a risk-of-bias criterion (sample size). When re-analysed to account for crossover data, opioids decreased breathlessness (standardised mean differences -0.32; -0.18 to -0.47; I2=44.8%) representing a clinically meaningful reduction of 0.8 points (0-10 numerical rating scale), consistent across meta-analyses.

Detaljer

Författare
  • Magnus Ekström
  • Sabrina Bajwah
  • J. Martin Bland
  • David C. Currow
  • Jamilla Hussain
  • Miriam J. Johnson
Enheter & grupper
Externa organisationer
  • King's College London
  • University of York
  • Flinders University
  • Hull York Medical School
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Biomedicinsk laboratorievetenskap/teknologi
  • Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)88-90
Antal sidor3
TidskriftThorax
Volym73
Utgivningsnummer1
StatusPublished - 2018
PublikationskategoriForskning
Peer review utfördJa