Ontogenic shifts in cellular fate are linked to proteotype changes in lineage-biased hematopoietic progenitor cells

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Jassinskaja et al. describe ontogeny-specific proteomic signatures and functionality of lineage-biased hematopoietic progenitor cells (HPCs). They uncover that fetal-specific features differ between lymphoid-competent and myeloid-restricted progenitors and reveal an ontogenic shift in monocyte differentiation capacity, partially driven by differential Irf8 expression between fetal and adult granulocyte-monocyte progenitors (GMPs).

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Hematologi

Nyckelord

Originalspråkengelska
Artikelnummer108894
TidskriftCell Reports
Volym34
Utgåva nummer12
StatusPublished - 2021
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Maria Jassinskaja, 2021, Lund: Lund University, Faculty of Medicine. 87 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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