Ophthalmic complications of Lemierre syndrome

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

Ophthalmic complications of Lemierre syndrome. / Kreuzpointner, Robert; Valerio, Luca; Corsi, Gabriele; Zane, Federica; Sacco, Clara; Holm, Karin; Righini, Christian; Pecci, Alessandro; Zweifel, Sandrine; Barco, Stefano.

I: Acta Ophthalmologica, 2021.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Kreuzpointner, R, Valerio, L, Corsi, G, Zane, F, Sacco, C, Holm, K, Righini, C, Pecci, A, Zweifel, S & Barco, S 2021, 'Ophthalmic complications of Lemierre syndrome', Acta Ophthalmologica. https://doi.org/10.1111/aos.14871

APA

Kreuzpointner, R., Valerio, L., Corsi, G., Zane, F., Sacco, C., Holm, K., Righini, C., Pecci, A., Zweifel, S., & Barco, S. (2021). Ophthalmic complications of Lemierre syndrome. Acta Ophthalmologica. https://doi.org/10.1111/aos.14871

CBE

Kreuzpointner R, Valerio L, Corsi G, Zane F, Sacco C, Holm K, Righini C, Pecci A, Zweifel S, Barco S. 2021. Ophthalmic complications of Lemierre syndrome. Acta Ophthalmologica. https://doi.org/10.1111/aos.14871

MLA

Vancouver

Author

Kreuzpointner, Robert ; Valerio, Luca ; Corsi, Gabriele ; Zane, Federica ; Sacco, Clara ; Holm, Karin ; Righini, Christian ; Pecci, Alessandro ; Zweifel, Sandrine ; Barco, Stefano. / Ophthalmic complications of Lemierre syndrome. I: Acta Ophthalmologica. 2021.

RIS

TY - JOUR

T1 - Ophthalmic complications of Lemierre syndrome

AU - Kreuzpointner, Robert

AU - Valerio, Luca

AU - Corsi, Gabriele

AU - Zane, Federica

AU - Sacco, Clara

AU - Holm, Karin

AU - Righini, Christian

AU - Pecci, Alessandro

AU - Zweifel, Sandrine

AU - Barco, Stefano

PY - 2021

Y1 - 2021

N2 - Purpose: Lemierre syndrome is a life-threatening condition characterized by head/neck bacterial infection, local suppurative thrombophlebitis and septic embolic complications in a range of sites of distant organs. No prior study focused on the course and characteristics of ophthalmic complications of Lemierre syndrome. Methods: We analysed data of 27 patients with ophthalmic complications from a large cohort of 712 cases with Lemierre syndrome reported globally between 2000 and 2017. We focused on initial manifestations, early (in-hospital) course and long-term ophthalmic deficits at the time of hospital discharge or during postdischarge follow-up. The study protocol was registered in the International Prospective Register of Systematic Reviews PROSPERO (CRD42016052572). Results: Nine (33%) patients were women; the median age was 20 (Q1–Q3: 15–33) years. Fusobacterium spp. was involved in 56% of cases. The most prevalent initial manifestations were decreased vision (35%) and periocular oedema (38%), followed by impaired eye movements/nerve palsy (28%) and proptosis (28%). Venous involvement, notably cerebral vein thrombosis (70%) and ophthalmic vein thrombosis (55%), explained the symptomatology in most cases. Septic embolism (7%), orbital abscesses (2%) and carotid stenosis (14%) were also present. Ophthalmic sequelae were reported in 9 (33%) patients, often consisting of blindness or reduced visual acuity, and nerve paralysis/paresis. Conclusion: Ophthalmic complications represent a severe manifestation of Lemierre syndrome, often reflecting an underlying cerebral vein thrombosis. Visual acuity loss and long-term severe complications are frequent. We call for an interdisciplinary approach to the management of patients with Lemierre syndrome and the routine involvement of ophthalmologists.

AB - Purpose: Lemierre syndrome is a life-threatening condition characterized by head/neck bacterial infection, local suppurative thrombophlebitis and septic embolic complications in a range of sites of distant organs. No prior study focused on the course and characteristics of ophthalmic complications of Lemierre syndrome. Methods: We analysed data of 27 patients with ophthalmic complications from a large cohort of 712 cases with Lemierre syndrome reported globally between 2000 and 2017. We focused on initial manifestations, early (in-hospital) course and long-term ophthalmic deficits at the time of hospital discharge or during postdischarge follow-up. The study protocol was registered in the International Prospective Register of Systematic Reviews PROSPERO (CRD42016052572). Results: Nine (33%) patients were women; the median age was 20 (Q1–Q3: 15–33) years. Fusobacterium spp. was involved in 56% of cases. The most prevalent initial manifestations were decreased vision (35%) and periocular oedema (38%), followed by impaired eye movements/nerve palsy (28%) and proptosis (28%). Venous involvement, notably cerebral vein thrombosis (70%) and ophthalmic vein thrombosis (55%), explained the symptomatology in most cases. Septic embolism (7%), orbital abscesses (2%) and carotid stenosis (14%) were also present. Ophthalmic sequelae were reported in 9 (33%) patients, often consisting of blindness or reduced visual acuity, and nerve paralysis/paresis. Conclusion: Ophthalmic complications represent a severe manifestation of Lemierre syndrome, often reflecting an underlying cerebral vein thrombosis. Visual acuity loss and long-term severe complications are frequent. We call for an interdisciplinary approach to the management of patients with Lemierre syndrome and the routine involvement of ophthalmologists.

KW - anticoagulation

KW - bacterial infection

KW - lemierre syndrome

KW - mycotic aneurysm

KW - ocular vein thrombosis

KW - rare disorders

U2 - 10.1111/aos.14871

DO - 10.1111/aos.14871

M3 - Article

C2 - 33829646

AN - SCOPUS:85104006084

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-3768

ER -