Optimization of image quality in breast tomosynthesis using lumpectomy and mastectomy specimens

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title = "Optimization of image quality in breast tomosynthesis using lumpectomy and mastectomy specimens",
abstract = "The purpose of this study was to determine how image quality in breast tomosynthesis (BT) is affected when acquisition modes are varied, using human breast specimens containing malignant tumors and/or microcalcifications. Images of thirty-one breast lumpectomy and mastectomy specimens were acquired on a BT prototype based on a Mammomat Novation (Siemens) full-field digital mammography system. BT image acquisitions of the same specimens were performed varying the number of projections, angular range, and detector signal collection mode (binned and non-binned in the scan direction). An enhanced filtered back projection reconstruction method was applied with constant settings of spectral and slice thickness filters. The quality of these images was evaluated via relative visual grading analysis (VGA) human observer performance experiments using image quality criteria. Results from the relative VGA study indicate that image quality increases with number of projections and angular range. A binned detector collecting mode results in less noise, but reduced resolution of structures. Human breast specimens seem to be suitable for comparing image sets in BT with image quality criteria.",
keywords = "Digital mammography systems, Breast tomosynthesis (BT), Visual grading analysis (VGA)",
author = "Pontus Timberg and Mark Ruschin and Magnus B{\aa}th and Bengt Hemdal and Ingvar Andersson and Tony Svahn and S{\"o}ren Mattsson and Anders Tingberg",
year = "2007",
doi = "10.1117/12.709703",
language = "English",
volume = "6510",
publisher = "SPIE",
number = "PART 2",
pages = "U1379--U1386",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
address = "United States",