Optimization of integrated chromatography sequences for purification of biopharmaceuticals

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

With continued development of integrated and continuous downstream purification processes, tuning and optimization become increasingly complicated with additional parameters and codependent variables over the sequence. This article offers a novel perspective of nonlinear optimization of integrated sequences with regard to individual column sizes, flow rates, and scheduling. The problem setup itself is a versatile tool to be used in downstream design which is demonstrated in two case studies: a four-column integrated sequence and a continuously loaded twin-capture setup with five columns.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Farmaceutisk synteskemi

Nyckelord

Originalspråkengelska
Artikelnummere2871
TidskriftBiotechnology Progress
Volym35
Utgåva nummer6
Tidigt onlinedatum2019 jun 17
StatusPublished - 2019 nov
PublikationskategoriForskning
Peer review utfördJa