Oral provocation of patients allergic to sesquiterpene lactones with German chamomile tea to demonstrate possible systemic allergic dermatitis

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Background: Most patients with contact allergy to Asteraceae plants are patch test positive to sesquiterpene lactone mix (SLM). There are several reports among these patients of a flare-up of hand eczema after ingestion of food and beverages originating from Asteraceae plants. Aim: To investigate whether German chamomile tea can elicit systemic allergic dermatitis. Patients and Methods: Individuals with or without contact allergy to SLM were patch tested with an extract of German chamomile tea. Six weeks later, they were provoked with capsules containing either freeze-dried German chamomile tea or placebo capsules containing lactose, in a double-blind, randomized study. A numerical rating scale (NRS) was used to ascertain the volunteers' opinion of their hand eczema status. The study individuals were examined to detect a possible flare-up of healed patch test reactions to chamomile. Results: None of the subjects had a flare-up of healed patch test reactions. According to the NRS, SLM-positive individuals experienced a significant worsening of hand eczema, independently of whether they received chamomile or lactose capsules. Conclusion: No evidence suggestive of systemic allergic dermatitis was found.


Enheter & grupper
Externa organisationer
  • Skåne University Hospital
  • Halmstad County Hospital

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Dermatologi och venereologi


TidskriftContact Dermatitis
StatusE-pub ahead of print - 2020
Peer review utfördJa