Oscillations in cortico-basal ganglia circuits: implications for Parkinson's disease and other neurologic and psychiatric conditions

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Cortico-basal ganglia circuits are thought to play a crucial role in the selection and control of motor behaviors and have also been implicated in the processing of motivational content and in higher cognitive functions. During the last two decades, electrophysiological recordings in basal ganglia circuits have shown that several disease conditions are associated with specific changes in the temporal patterns of neuronal activity. In particular, synchronized oscillations have been a frequent finding suggesting that excessive synchronization of neuronal activity may be a pathophysiological mechanism involved in a wide range of neurologic and psychiatric conditions. We here review the experimental support for this hypothesis primarily in relation to Parkinson's disease but also in relation to dystonia, essential tremor, epilepsy, and psychosis/schizophrenia.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • University of Chile
  • Federal University of Paraná
  • Umeå University
  • Federal University of São Francisco Valley
  • Metropolitan University of Educational Sciences
  • INACAP Technological University of Chile
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper
  • Psykologi (exklusive tillämpad psykologi)

Nyckelord

Originalspråkengelska
Sidor (från-till)203-231
Antal sidor29
TidskriftJournal of Neurophysiology
Volym122
Utgåva nummer1
StatusPublished - 2019 jul
PublikationskategoriForskning
Peer review utfördJa