Overexpression of podocalyxin-like protein is an independent factor of poor prognosis in colorectal cancer.

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Bibtex

@article{f6be382cda3a45fb8e39f76dfbe82f50,
title = "Overexpression of podocalyxin-like protein is an independent factor of poor prognosis in colorectal cancer.",
abstract = "Background:Podocalyxin-like 1 (PODXL) is a cell-adhesion glycoprotein and stem cell marker that has been associated with an aggressive tumour phenotype and poor prognosis in several forms of cancer. In this study, we investigated the prognostic impact of PODXL expression in colorectal cancer (CRC).Methods:Using tissue microarrays and immunohistochemistry, PODXL expression was evaluated in 536 incident CRC cases from a prospective, population-based cohort study. Kaplan-Meier analysis and Cox proportional hazards modelling were used to assess the impact of PODXL expression on cancer-specific survival (CSS) and overall survival (OS).Results:High PODXL expression was significantly associated with unfavourable clinicopathological characteristics, a shorter CSS (hazard ratio (HR)=1.98; 95{\%} confidence interval (CI) 1.38-2.84, P<0.001) and 5-year OS (HR=1.85; 95{\%} CI 1.29-2.64, P=0.001); the latter remaining significant in multivariate analysis (HR=1.52; 95{\%} CI 1.03-2.25, P=0.036). In addition, in curatively resected stage III (T1-4, N1-2, M0) patients (n=122) with tumours with high PODXL expression, a significant benefit from adjuvant chemotherapy was demonstrated (p(interaction) =0.004 for CSS and 0.015 for 5-year OS in multivariate analysis).Conclusion:Podocalyxin-like 1 expression is an independent factor of poor prognosis in CRC. Our results also suggest that PODXL may be a useful marker to stratify patients for adjuvant chemotherapy.",
author = "Larsson, {Anna H} and Martin Johansson and Sakarias Wangefjord and Alexander Gaber and Bj{\"o}rn Nodin and Paulina Kucharzewska and Charlotte Welinder and Mattias Belting and Jakob Eberhard and Anders Johnsson and M Uhlen and Karin Jirstr{\"o}m",
note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000), Pathology (Malm{\"o}) (013031000)",
year = "2011",
doi = "10.1038/bjc.2011.295",
language = "English",
volume = "105",
pages = "666--672",
journal = "British Journal of Cancer",
issn = "1532-1827",
publisher = "Nature Publishing Group",
number = "5",

}