Oxidized limonene and oxidized linalool - concomitant contact allergy to common fragrance terpenes.

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Limonene and linalool are common fragrance terpenes. Both oxidized R-limonene and oxidized linalool have recently been patch tested in an international setting, showing contact allergy in 5.2% and 6.9% of dermatitis patients, respectively.

To investigate concomitant reactions between oxidized R-limonene and oxidized linalool in consecutive dermatitis patients.

Oxidized R-limonene 3.0% (containing limonene hydroperoxides 0.33%) and oxidized linalool 6% (linalool hydroperoxides 1%) in petrolatum were tested in 2900 consecutive dermatitis patients in Australia, Denmark, Singapore, Spain, Sweden, and the United Kingdom.

A total of 281 patients reacted to either oxidized R-limonene or oxidized linalool. Of these, 25% had concomitant reactions to both compounds, whereas 29% reacted only to oxidized R-limonene and 46% only to oxidized linalool. Of the 152 patients reacting to oxidized R-limonene, 46% reacted to oxidized linalool, whereas 35% of the 200 patients reacting to oxidized linalool also reacted to oxidized R-limonene.

The majority of the patients (75%) reacted to only one of the oxidation mixtures, thus supporting the specificity of the reactions. The concomitant reactions to the two fragrance allergens suggest multiple sensitizations, which most likely reflect the exposure to the different fragrance materials in various types of consumer products. This is in accordance with what is generally seen for patch test reactions to fragrance materials.


  • Johanna Bråred Christensson
  • Ann-Therese Karlberg
  • Klaus E Andersen
  • Magnus Bruze
  • Jeanne D Johansen
  • Begoña Garcia-Bravo
  • Ana Giménez Arnau
  • Chee-Leok Goh
  • Rosemary Nixon
  • Ian R White
Enheter & grupper
Externa organisationer
  • Göteborgs universitet
  • Odense University Hospital
  • University of Copenhagen
  • University Hospital Virgen Macarena
  • National Skin Centre
  • Occupational Dermatology Research and Education Centre
  • Guy's and St Thomas' NHS Foundation Trust
  • Autonomous University of Barcelona

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Dermatologi och venereologi
TidskriftContact Dermatitis
Tidigt onlinedatum2016 feb 26
StatusPublished - 2016
Peer review utfördJa