OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(-/-) mice aortas

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Oxidized low density lipoprotein (oxLDL) contributes to the pathophysiology of atherosclerosis, partly by altering gene expression in vascular cells. Here, we show 221 genes differentially regulated by oxLDL in coronary artery smooth muscle cells (CASMC), using oligonucleotide microarrays. These genes were classified into 14 functional groups. A comparable gene expression pattern was detected in apoE(-/-) mice. OxLDL induced an oxidative stress response in CASMC, but not the unfolded protein response. OxLDL also caused CASMC death which was accompanied by increased expression of FasL, Bax, and p53 but was caspase-independent. This approach provides further insight into disease pathology and prognosis. (c) 2007 Elsevier Inc. All rights reserved.

Detaljer

Författare
  • Janice L. V. Reeve
  • Catherine Stenson-Cox
  • Aideen O'Doherty
  • Isabella Porn-Ares
  • Mikko Ares
  • Timothy O'Brien
  • Afshin Samali
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Biologiska vetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)681-686
TidskriftBiochemical and Biophysical Research Communications
Volym356
Utgivningsnummer3
StatusPublished - 2007
PublikationskategoriForskning
Peer review utfördJa