Ozonation of Sitagliptin: Removal Kinetics and Elucidation of Oxidative Transformation Products

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Due to the increasing use and high excretion rates, high quantities of the antidiabetic drug sitagliptin (STG) enter wastewater treatment plants (WWTPs). In conventional biological treatment, only a moderate removal was achieved, and thus, STG can be detected in WWTP effluents with concentrations in the higher ng/L range. Ozonation is a widely discussed technique for advanced wastewater treatment. In lab-scale experiments, STG showed pH-dependent removal kinetics with a maximum apparent rate constant of k ∼1 × 104 M-1 s-1 at pH ≥ 9. With an apparent rate constant of kO3 = (1.8 ± 0.7) × 103 M-1 s-1 at pH 8, STG can be considered to be readily degraded by ozonation of WWTP effluents. Ozone attacks the primary amine moiety of STG, leading to nitro-STG (TP 437) (the primary amine moiety is transformed into a nitro group). Furthermore, a diketone (TP 406) was formed, which can be further degraded by ozone. Lab-scale and pilot-scale experiments on ozonation of WWTP effluents confirmed that the ozone attack of STG was incomplete even at high ozone doses of 1.7 and 0.9 mg O3/mg DOC, respectively. These experiments confirmed that nitro-STG was formed as the main TP in the wastewater matrix. Two other TPs, TP 421c and TP 206b, were also detected, albeit with low intensities.


  • Nina Hermes
  • Kevin S. Jewell
  • Per Falås
  • Holger V. Lutze
  • Arne Wick
  • Thomas A. Ternes
Enheter & grupper
Externa organisationer
  • Federal Institute of Hydrology
  • University of Duisburg-Essen

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Naturresursteknik
Sidor (från-till)10588-10598
Antal sidor11
TidskriftEnvironmental Science and Technology
Utgåva nummer17
Tidigt onlinedatum2020 aug 11
StatusPublished - 2020
Peer review utfördJa