Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.

Forskningsoutput: TidskriftsbidragÖversiktsartikel


Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately experienced by the vast majority of patients. In addition, psychiatric conditions often manifested as compulsive behaviours, are emerging as a serious problem in the management of L-dopa therapy. The present review attempts to provide an overview of our current understanding of dyskinesia and other L-dopa-induced dysfunctions, a field that dramatically evolved in the past twenty years. In view of the extensive literature on LID, there appeared a critical need to re-frame the concepts, to highlight the most suitable models, to review the central nervous system (CNS) circuitry that may be involved, and to propose a pathophysiological framework was timely and necessary. An updated review to clarify our understanding of LID and other L-dopa-related side effects was therefore timely and necessary. This review should help in the development of novel therapeutic strategies aimed at preventing the generation of dyskinetic symptoms.


  • Matthieu F Bastide
  • Wassilios G Meissner
  • Barbara Picconi
  • Stefania Fasano
  • Pierre-Olivier Fernagut
  • Michael Feyder
  • Veronica Francardo
  • Yunmin Ding
  • Riccardo Brambilla
  • Gilberto Fisone
  • A Jon Stoessl
  • Mathieu Bourdenx
  • Michel Engeln
  • Sylvia Navailles
  • Philippe De Deurwaerdère
  • Wai Kin D Ko
  • Nicola Simola
  • Micaela Morelli
  • Laurent Groc
  • Maria-Cruz Rodriguez
  • Eugenia V Gurevich
  • Maryka Quik
  • Michele Morari
  • Manuela Mellone
  • Fabrizio Gardoni
  • Elisabetta Tronci
  • Dominique Guehl
  • François Tison
  • Alan R Crossman
  • Un Jung Kang
  • Kathy Steece-Collier
  • Susan Fox
  • Manolo Carta
  • Erwan Bézard
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi
Sidor (från-till)96-168
TidskriftProgress in Neurobiology
Utgåva nummerJul 21
StatusPublished - 2015
Peer review utfördJa