Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.

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title = "Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.",
abstract = "Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately experienced by the vast majority of patients. In addition, psychiatric conditions often manifested as compulsive behaviours, are emerging as a serious problem in the management of L-dopa therapy. The present review attempts to provide an overview of our current understanding of dyskinesia and other L-dopa-induced dysfunctions, a field that dramatically evolved in the past twenty years. In view of the extensive literature on LID, there appeared a critical need to re-frame the concepts, to highlight the most suitable models, to review the central nervous system (CNS) circuitry that may be involved, and to propose a pathophysiological framework was timely and necessary. An updated review to clarify our understanding of LID and other L-dopa-related side effects was therefore timely and necessary. This review should help in the development of novel therapeutic strategies aimed at preventing the generation of dyskinetic symptoms.",
author = "Bastide, {Matthieu F} and Meissner, {Wassilios G} and Barbara Picconi and Stefania Fasano and Pierre-Olivier Fernagut and Michael Feyder and Veronica Francardo and Cristina Alcacer and Yunmin Ding and Riccardo Brambilla and Gilberto Fisone and {Jon Stoessl}, A and Mathieu Bourdenx and Michel Engeln and Sylvia Navailles and {De Deurwaerd{\`e}re}, Philippe and Ko, {Wai Kin D} and Nicola Simola and Micaela Morelli and Laurent Groc and Maria-Cruz Rodriguez and Gurevich, {Eugenia V} and Maryka Quik and Michele Morari and Manuela Mellone and Fabrizio Gardoni and Elisabetta Tronci and Dominique Guehl and Fran{\cc}ois Tison and Crossman, {Alan R} and Kang, {Un Jung} and Kathy Steece-Collier and Susan Fox and Manolo Carta and {Cenci Nilsson}, Angela and Erwan B{\'e}zard",
year = "2015",
doi = "10.1016/j.pneurobio.2015.07.002",
language = "English",
volume = "132",
pages = "96--168",
journal = "Progress in Neurobiology",
issn = "1873-5118",
publisher = "Elsevier",
number = "Jul 21",