Patience is the key: Contraceptive induced chorea in a girl with Down Syndrome

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Background Isolated (sub)acute chorea in young patients is a relatively rare movement disorder with a broad differential diagnosis, including drug-induced, post-infectious, auto-immunological and vascular aetiologies. Case presentation We describe an adolescent girl with Down's syndrome presenting with chorea due to oral contraceptive usage. After discontinuation of the oral contraceptive it took several months before the symptoms disappeared. Although generally well recognised, it is important to realise this delayed effect. Rejecting the diagnosis too soon may lead to unnecessary treatment for other possible underlying aetiologies, especially in patients with Down Syndrome, known to be vulnerable for autoimmune disorders. Conclusion We plead for discontinuation for at least three months before exclusion of oral contraceptives as cause of chorea.


  • Hendriekje Eggink
  • Anouk Kuiper
  • Cathérine C.S. Delnooz
  • Deborah A. Sival
  • Tom J. De Koning
  • Marina A.J. Tijssen
Externa organisationer
  • University Medical Center Groningen

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Psykiatri


Sidor (från-till)671-673
Antal sidor3
TidskriftEuropean Journal of Paediatric Neurology
Utgåva nummer4
StatusPublished - 2016 jul 1
Peer review utfördJa
Externt publiceradJa