PDGF-B Is Required for Development of the Glymphatic System

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently coincided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse line Pdgfb ret/ret suppressed the development of the glymphatic system, whose functions remained suppressed in adulthood compared with wild-type mice. These experiments map the natural development of the glymphatic system in mice and define a critical role of PDGF-B in the development of perivascular CSF transport.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • University of Rochester
  • University of Copenhagen
  • Uppsala universitet, Historiska institutionen
  • Karolinska Institute
  • Mansoura University
  • Mansoura University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cell- och molekylärbiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)2955-2969.e3
TidskriftCell Reports
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa