PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.

Detaljer

Författare
  • X. Li
  • A. Pontén
  • K. Aase
  • L. Karlsson
  • A. Abramsson
  • M. Uutela
  • G. Bäckström
  • M. Hellström
  • Hans Ehrencrona
  • H. Li
  • P. Soriano
  • C. Betsholtz
  • C. H. Heldin
  • K. Alitalo
  • A. Ostman
  • U. Eriksson
Externa organisationer
  • External Organization - Unknown
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cell- och molekylärbiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)302-309
TidskriftNature Cell Biology
Volym2
Utgivningsnummer5
StatusPublished - 2000
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa