Peptide interactions with bacterial lipopolysaccharides

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Standard

Peptide interactions with bacterial lipopolysaccharides. / Schmidtchen, Artur; Malmsten, Martin.

I: Current Opinion in Colloid & Interface Science, Vol. 18, Nr. 5, 2013, s. 381-392.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Harvard

APA

CBE

MLA

Vancouver

Author

RIS

TY - JOUR

T1 - Peptide interactions with bacterial lipopolysaccharides

AU - Schmidtchen, Artur

AU - Malmsten, Martin

PY - 2013

Y1 - 2013

N2 - Peptide and protein interactions with (lipo)polysaccharides are important in various biological contexts, including lipoprotein deposition at proteoglycan-covered endothelial surfaces in atherosclerosis, lectin functionality, and the interaction of antimicrobial and anti-inflammatory peptides and proteins with (lipo)polysaccharides. The latter of these areas, which is the topic of this review, has attracted considerable interest during the last few years, since antimicrobial peptides may offer novel therapeutic opportunities in an era of growing problems with antibiotic resistance, and persisting problems with both acute and chronic inflammation. In the present overview, physicochemical factors affecting peptide interactions with bacterial (lipo)polysaccharides are discussed, both in solution and at membrane interfaces. In doing so, an attempt is made to illustrate how physicochemical factors affect the antimicrobial and anti-endotoxic functionality of such peptides, and how knowledge on this can be translated into therapeutic opportunities, e.g., in sepsis. (C) 2013 Elsevier Ltd. All rights reserved.

AB - Peptide and protein interactions with (lipo)polysaccharides are important in various biological contexts, including lipoprotein deposition at proteoglycan-covered endothelial surfaces in atherosclerosis, lectin functionality, and the interaction of antimicrobial and anti-inflammatory peptides and proteins with (lipo)polysaccharides. The latter of these areas, which is the topic of this review, has attracted considerable interest during the last few years, since antimicrobial peptides may offer novel therapeutic opportunities in an era of growing problems with antibiotic resistance, and persisting problems with both acute and chronic inflammation. In the present overview, physicochemical factors affecting peptide interactions with bacterial (lipo)polysaccharides are discussed, both in solution and at membrane interfaces. In doing so, an attempt is made to illustrate how physicochemical factors affect the antimicrobial and anti-endotoxic functionality of such peptides, and how knowledge on this can be translated into therapeutic opportunities, e.g., in sepsis. (C) 2013 Elsevier Ltd. All rights reserved.

KW - Anti-endotoxic

KW - Antimicrobial

KW - Lipid A

KW - Lipopolysaccharide

KW - Peptide

U2 - 10.1016/j.cocis.2013.06.003

DO - 10.1016/j.cocis.2013.06.003

M3 - Review article

VL - 18

SP - 381

EP - 392

JO - Current Opinion in Colloid and Interface Science

JF - Current Opinion in Colloid and Interface Science

SN - 1359-0294

IS - 5

ER -