Peptide-containing nerve fibres in normal human parathyroid glands and in human parathyroid adenomas

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Peptide-containing nerve fibres in normal human parathyroid glands and in human parathyroid adenomas. / Luts, L; Bergenfelz, A; Alumets, J; Sundler, F.

I: European Journal of Endocrinology, Vol. 133, Nr. 5, 11.1995, s. 543-51.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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T1 - Peptide-containing nerve fibres in normal human parathyroid glands and in human parathyroid adenomas

AU - Luts, L

AU - Bergenfelz, A

AU - Alumets, J

AU - Sundler, F

PY - 1995/11

Y1 - 1995/11

N2 - There are only a few studies on the innervation of the human parathyroid glands and the content of neurotransmitters. We therefore studied the occurrence and distribution of peptide-containing and adrenergic nerve fibres and the coexistence pattern of neuromessengers by immunocytochemistry in normal (unaffected) and adenomatous parathyroid glands from patients undergoing surgery for parathyroid adenoma. The unaffected parathyroid glands had a moderate-to-rich supply of nerve fibres and terminals containing two general neuronal markers, protein gene product 9.5 (PGP 9.5) and synaptophysin, neuropeptide Y (NPY) and tyrosine hydroxylase (TH). They were seen close to blood vessels and, occasionally, among the endocrine cells. Only a few nerves contained calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP), substance P (SP) and pituitary adenylate cyclase-activating peptide (PACAP). The general density of innervation, using PGP 9.5 and synaptophysin as markers, varied greatly among the different adenomas examined. This applied also to the density of fibres and terminals containing specific types of messengers. Some of the tumours had a rich supply of TH- and NPY-containing nerve fibres, while others contained only few scattered fibres. The CGRP-containing fibres varied from moderate in number to no detectable fibres. The PACAP-, SP- and VIP-containing fibres were always very few or not detectable. It is not inconceivable that the wide variation in general density of the innervation and frequency of peptide-containing nerves among individual parathyroid adenomas is of significance for their hormone secretory behaviour.

AB - There are only a few studies on the innervation of the human parathyroid glands and the content of neurotransmitters. We therefore studied the occurrence and distribution of peptide-containing and adrenergic nerve fibres and the coexistence pattern of neuromessengers by immunocytochemistry in normal (unaffected) and adenomatous parathyroid glands from patients undergoing surgery for parathyroid adenoma. The unaffected parathyroid glands had a moderate-to-rich supply of nerve fibres and terminals containing two general neuronal markers, protein gene product 9.5 (PGP 9.5) and synaptophysin, neuropeptide Y (NPY) and tyrosine hydroxylase (TH). They were seen close to blood vessels and, occasionally, among the endocrine cells. Only a few nerves contained calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP), substance P (SP) and pituitary adenylate cyclase-activating peptide (PACAP). The general density of innervation, using PGP 9.5 and synaptophysin as markers, varied greatly among the different adenomas examined. This applied also to the density of fibres and terminals containing specific types of messengers. Some of the tumours had a rich supply of TH- and NPY-containing nerve fibres, while others contained only few scattered fibres. The CGRP-containing fibres varied from moderate in number to no detectable fibres. The PACAP-, SP- and VIP-containing fibres were always very few or not detectable. It is not inconceivable that the wide variation in general density of the innervation and frequency of peptide-containing nerves among individual parathyroid adenomas is of significance for their hormone secretory behaviour.

KW - Adenoma

KW - Calcitonin Gene-Related Peptide

KW - Female

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Middle Aged

KW - Nerve Fibers

KW - Neuropeptides

KW - Parathyroid Glands

KW - Parathyroid Neoplasms

KW - Pituitary Adenylate Cyclase-Activating Polypeptide

KW - Substance P

KW - Synaptophysin

KW - Thiolester Hydrolases

KW - Tyrosine 3-Monooxygenase

KW - Ubiquitin Thiolesterase

KW - Vasoactive Intestinal Peptide

U2 - 10.1530/eje.0.1330543

DO - 10.1530/eje.0.1330543

M3 - Article

C2 - 7581983

VL - 133

SP - 543

EP - 551

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 1479-683X

IS - 5

ER -