Pharmacokinetic and biodistribution study following systemic administration of Fospeg - a Pegylated liposomal mTHPC formulation in a murine model

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Abstract in Undetermined Fospeg® is a newly developed photosensitizer formulation based on meso-tetra(hydroxyphenyl)chlorin (mTHPC), with hydrophilic liposomes to carry the hydrophobic photosensitizer to the target tissue. In this study the pharmacokinetics and biodistribution of Fospeg® were investigated by high performance liquid chromatography at various times (0.5-18 hours) following systemic i.v. administration. As a model an experimental HT29 colon tumor in NMRI nu/nu mice was employed. Our study indicates a higher plasma peak concentration, a longer circulation time and a better tumor-to-skin ratio than those of Foslip®, another liposomal mTHPC formulation. Data from ex vivo tissue fluorescence and reflectance imaging exhibit good correlation with chemical extraction. Our results have shown that optical imaging provides the potential for fluorophore quantification in biological tissues. (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim).

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Biolitec Research GmbH
  • National Technical University of Athens
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
  • Dermatologi och venereologi

Nyckelord

Originalspråkengelska
Sidor (från-till)142-152
TidskriftJournal of Biophotonics
Volym8
Utgåva nummer1-2
StatusPublished - 2015
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Haiyan Xie, 2014, Lund University. 198 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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