Pharmacokinetics of Na2B12H11SH (BSH) in patients with malignant brain tumours as prerequisite for a phase I clinical trial of boron neutron capture

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Abstract

The disposition of Na2B12H11SH (BSH) in patients with malignant glioma has been investigated, in preparation for a Phase I clinical trial of boron neutron capture therapy. BSH was found to possess a linear disposition over the dosage interval investigated (up to 75 mg/kg). A bi-phasic blood pharmacokinetics was observed. Tumour-to-blood ratios showed variations between patients between 0.08 and 5.1. The data allow the definition of amount of BSH and timing of infusion for a Phase I clinical trial protocol.

Detaljer

Författare
  • D Gabel
  • D Preusse
  • D Haritz
  • F Grochulla
  • K Haselsberger
  • H Fankhauser
  • Crister Ceberg
  • H D Peters
  • U Klotz
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Radiologi och bildbehandling

Nyckelord

Originalspråkengelska
Sidor (från-till)606-612
TidskriftActa Neurochirurgica
Volym139
Utgivningsnummer7
StatusPublished - 1997
PublikationskategoriForskning
Peer review utfördJa