Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Background: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. Objective: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Design: A total of 856 patients with newly diagnosed UCC were matched with 856 cohort members by sex, age at baseline, study center, date and time of blood collection, and fasting status. Plasma carotenoids (alpha- and beta-carotene, beta-cryptoxanthin, lycopene, lutein, and zeaxanthin) were measured by using reverse-phase HPLC, and plasma vitamin C was measured by using a colorimetric assay. Incidence rate ratios (IRRs) were estimated by using conditional logistic regression with adjustment for smoking status, duration, and intensity. Results: UCC risk decreased with higher concentrations of the sum of plasma carotenoids (IRR for the highest compared with the lowest quartile: 0.64; 95% CI: 0.44, 0.93; P-trend = 0.04). Plasma beta-carotene was inversely associated with aggressive UCC (IRR: 0.51; 95% CI: 0.30, 0.88; P-trend = 0.02). Plasma lutein was inversely associated with risk of nonaggressive UCC (IRR: 0.56; 95% CI: 0.32, 0.98; P-trend = 0.05). No association was observed between plasma vitamin C and risk of UCC. Conclusions: Although residual confounding by smoking or other factors cannot be excluded, higher concentrations of plasma carotenoids may reduce risk of UCC, in particular aggressive UCC. Plasma lutein may reduce risk of nonaggressive UCC. Am J Clin Nutr 2012;96:902-10.


  • Martine M. Ros
  • H. Bas Bueno-de-Mesquita
  • Ellen Kampman
  • Katja K. H. Aben
  • Frederike L. Buechner
  • Eugene H. J. M. Jansen
  • Carla H. van Gils
  • Lars Egevad
  • Kim Overvad
  • Anne Tjonneland
  • Nina Roswall
  • Marie Christine Boutron-Ruault
  • Marina Kvaskoff
  • Florence Perquier
  • Rudolf Kaaks
  • Jenny Chang-Claude
  • Steffen Weikert
  • Heiner Boeing
  • Antonia Trichopoulou
  • Pagona Lagiou
  • Vardis Dilis
  • Domenico Palli
  • Valeria Pala
  • Carlotta Sacerdote
  • Rosario Tumino
  • Salvatore Panico
  • Petra H. M. Peeters
  • Inger T. Gram
  • Guri Skeie
  • Jose Maria Huerta
  • Aurelio Barricarte
  • Jose Ramon Quiros
  • Maria Jose Sanchez
  • Genevieve Buckland
  • Nerea Larranaga
  • Roy Ehrnström
  • Boerje L. Jungberg
  • Goeran Hallmans
  • Timothy J. Key
  • Naomi E. Allen
  • Kay-Tee Khaw
  • Nick Wareham
  • Paul Brennan
  • Elio Riboli
  • Lambertus A. Kiemeney
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Näringslära
Sidor (från-till)902-910
TidskriftAmerican Journal of Clinical Nutrition
StatusPublished - 2012
Peer review utfördJa