Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies

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Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies. / Kalapotharakos, Grigorios; Murtoniemi, Katja; Åkerström, Bo; Hämäläinen, Esa; Kajantie, Eero; Räikkönen, Katri; Villa, Pia; Laivuori, Hannele; Hansson, Stefan R.

I: Frontiers in Physiology, Vol. 10, 300, 2019.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Kalapotharakos, G, Murtoniemi, K, Åkerström, B, Hämäläinen, E, Kajantie, E, Räikkönen, K, Villa, P, Laivuori, H & Hansson, SR 2019, 'Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies', Frontiers in Physiology, vol. 10, 300. https://doi.org/10.3389/fphys.2019.00300

APA

Kalapotharakos, G., Murtoniemi, K., Åkerström, B., Hämäläinen, E., Kajantie, E., Räikkönen, K., Villa, P., Laivuori, H., & Hansson, S. R. (2019). Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies. Frontiers in Physiology, 10, [300]. https://doi.org/10.3389/fphys.2019.00300

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MLA

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Author

Kalapotharakos, Grigorios ; Murtoniemi, Katja ; Åkerström, Bo ; Hämäläinen, Esa ; Kajantie, Eero ; Räikkönen, Katri ; Villa, Pia ; Laivuori, Hannele ; Hansson, Stefan R. / Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies. I: Frontiers in Physiology. 2019 ; Vol. 10.

RIS

TY - JOUR

T1 - Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies

AU - Kalapotharakos, Grigorios

AU - Murtoniemi, Katja

AU - Åkerström, Bo

AU - Hämäläinen, Esa

AU - Kajantie, Eero

AU - Räikkönen, Katri

AU - Villa, Pia

AU - Laivuori, Hannele

AU - Hansson, Stefan R

PY - 2019

Y1 - 2019

N2 - Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of plasma A1M is increased in the late second trimester in high-risk controls, suggesting activation of endogenous protective system against oxidative stress.

AB - Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of plasma A1M is increased in the late second trimester in high-risk controls, suggesting activation of endogenous protective system against oxidative stress.

U2 - 10.3389/fphys.2019.00300

DO - 10.3389/fphys.2019.00300

M3 - Article

C2 - 31019465

VL - 10

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

M1 - 300

ER -