Plasma lipolytic activity after subcutaneous administration of heparin and a low molecular weight heparin fragment

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Plasma lipolytic activity after subcutaneous administration of heparin and a low molecular weight heparin fragment. / Persson, E; Nordenstrom, J; Hagenfeldt, L; Nilsson-Ehle, Peter.

I: Thrombosis Research, Vol. 46, Nr. 5, 1987, s. 697-704.

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T1 - Plasma lipolytic activity after subcutaneous administration of heparin and a low molecular weight heparin fragment

AU - Persson, E

AU - Nordenstrom, J

AU - Hagenfeldt, L

AU - Nilsson-Ehle, Peter

PY - 1987

Y1 - 1987

N2 - The effect of heparin and a low molecular weight heparin fragment (LMWH, mean molecular weight 4000-6000) on plasma anticoagulation and lipolysis was studied in eight healthy men. The activities of antifactor Xa (antiFXa), lipoprotein lipase (LPL), hepatic lipase (HL) and plasma levels of free fatty acids (FFA) were analysed after the injection of 5000 antiFXa units of heparin or LMWH subcutaneously. In comparison with heparin, the administration of LMWH resulted in a significantly higher antiFXa activity (p less than 0.001) but a lower release of LPL and HL (p less than 0.001), which did not increase plasma FFA. It is concluded that subcutaneous injection of LMWH in men elicits an adequate anticoagulant effect measured as antiFXa activity but has a negligible effect on plasma lipolytic activity.

AB - The effect of heparin and a low molecular weight heparin fragment (LMWH, mean molecular weight 4000-6000) on plasma anticoagulation and lipolysis was studied in eight healthy men. The activities of antifactor Xa (antiFXa), lipoprotein lipase (LPL), hepatic lipase (HL) and plasma levels of free fatty acids (FFA) were analysed after the injection of 5000 antiFXa units of heparin or LMWH subcutaneously. In comparison with heparin, the administration of LMWH resulted in a significantly higher antiFXa activity (p less than 0.001) but a lower release of LPL and HL (p less than 0.001), which did not increase plasma FFA. It is concluded that subcutaneous injection of LMWH in men elicits an adequate anticoagulant effect measured as antiFXa activity but has a negligible effect on plasma lipolytic activity.

KW - Heparin

KW - hepatic lipase

KW - lipoprotein lipase

KW - low molecular weight heparin

U2 - 10.1016/0049-3848(87)90271-4

DO - 10.1016/0049-3848(87)90271-4

M3 - Article

VL - 46

SP - 697

EP - 704

JO - Thrombosis Research

JF - Thrombosis Research

SN - 1879-2472

IS - 5

ER -