Plasma protein profiling in a stage defined pancreatic cancer cohort – Implications for early diagnosis

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a disease where detection preceding clinical symptoms significantly increases the life expectancy of patients. In this study, a recombinant antibody microarray platform was used to analyze 213 Chinese plasma samples from PDAC patients and normal control (NC) individuals. The cohort was stratified according to disease stage, i.e. resectable disease (stage I/II), locally advanced (stage III) and metastatic disease (stage IV). Support vector machine analysis showed that all PDAC stages could be discriminated from controls and that the accuracy increased with disease progression, from stage I to IV. Patients with stage I/II PDAC could be discriminated from NC with high accuracy based on a plasma protein signature, indicating a possibility for early diagnosis and increased detection rate of surgically resectable tumors.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Immunovia AB
  • Tianjin Medical University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi

Nyckelord

Originalspråkengelska
Sidor (från-till)1305-1316
Antal sidor12
TidskriftMolecular Oncology
Volym10
Utgivningsnummer8
StatusPublished - 2016 okt 1
PublikationskategoriForskning
Peer review utfördJa