Poly(hydroxyethyl methacrylate)-based macroporous hydrogels with disulfide cross-linker

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Biodegradable supermacroporous PHEMA cryogels were produced by combining two cross-linkers, poly(ethylene glycol) diacrylate and a newly developed disulfide water soluble crosslinker, N,N'-bis(methacryloyl)-L-cystine. The biodegradable PHEMA cryogels were prepared with gel fraction yields up to 70% and were characterized by highly interconnected pores of micrometer size and good mechanical stability. When subjected to reductive agents like DTT, the biodegradable PHEMA cryogels disintegrated into small pieces. The rate of disintegration was controlled by the crosslinking density in the cryogels and the DTT concentration.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Industriell bioteknik

Nyckelord

Originalspråkengelska
Sidor (från-till)577-584
TidskriftMacromolecular Chemistry and Physics
Volym209
Utgåva nummer6
StatusPublished - 2008
PublikationskategoriForskning
Peer review utfördJa