Polymorphisms in DCDC2 and S100B associate with developmental dyslexia

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Polymorphisms in DCDC2 and S100B associate with developmental dyslexia. / Matsson, Hans; Huss, Mikael; Persson, Helena; Einarsdottir, Elisabet; Tiraboschi, Ettore; Nopola-Hemmi, Jaana; Schumacher, Johannes; Neuhoff, Nina; Warnke, Andreas; Lyytinen, Heikki; Schulte-Körne, Gert; Nöthen, Markus M; Leppänen, Paavo H T; Peyrard-Janvid, Myriam; Kere, Juha.

I: Journal of Human Genetics, Vol. 60, Nr. 7, 07.2015, s. 399-401.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Matsson, H, Huss, M, Persson, H, Einarsdottir, E, Tiraboschi, E, Nopola-Hemmi, J, Schumacher, J, Neuhoff, N, Warnke, A, Lyytinen, H, Schulte-Körne, G, Nöthen, MM, Leppänen, PHT, Peyrard-Janvid, M & Kere, J 2015, 'Polymorphisms in DCDC2 and S100B associate with developmental dyslexia', Journal of Human Genetics, vol. 60, nr. 7, s. 399-401. https://doi.org/10.1038/jhg.2015.37

APA

Matsson, H., Huss, M., Persson, H., Einarsdottir, E., Tiraboschi, E., Nopola-Hemmi, J., ... Kere, J. (2015). Polymorphisms in DCDC2 and S100B associate with developmental dyslexia. Journal of Human Genetics, 60(7), 399-401. https://doi.org/10.1038/jhg.2015.37

CBE

Matsson H, Huss M, Persson H, Einarsdottir E, Tiraboschi E, Nopola-Hemmi J, Schumacher J, Neuhoff N, Warnke A, Lyytinen H, Schulte-Körne G, Nöthen MM, Leppänen PHT, Peyrard-Janvid M, Kere J. 2015. Polymorphisms in DCDC2 and S100B associate with developmental dyslexia. Journal of Human Genetics. 60(7):399-401. https://doi.org/10.1038/jhg.2015.37

MLA

Vancouver

Matsson H, Huss M, Persson H, Einarsdottir E, Tiraboschi E, Nopola-Hemmi J et al. Polymorphisms in DCDC2 and S100B associate with developmental dyslexia. Journal of Human Genetics. 2015 jul;60(7):399-401. https://doi.org/10.1038/jhg.2015.37

Author

Matsson, Hans ; Huss, Mikael ; Persson, Helena ; Einarsdottir, Elisabet ; Tiraboschi, Ettore ; Nopola-Hemmi, Jaana ; Schumacher, Johannes ; Neuhoff, Nina ; Warnke, Andreas ; Lyytinen, Heikki ; Schulte-Körne, Gert ; Nöthen, Markus M ; Leppänen, Paavo H T ; Peyrard-Janvid, Myriam ; Kere, Juha. / Polymorphisms in DCDC2 and S100B associate with developmental dyslexia. I: Journal of Human Genetics. 2015 ; Vol. 60, Nr. 7. s. 399-401.

RIS

TY - JOUR

T1 - Polymorphisms in DCDC2 and S100B associate with developmental dyslexia

AU - Matsson, Hans

AU - Huss, Mikael

AU - Persson, Helena

AU - Einarsdottir, Elisabet

AU - Tiraboschi, Ettore

AU - Nopola-Hemmi, Jaana

AU - Schumacher, Johannes

AU - Neuhoff, Nina

AU - Warnke, Andreas

AU - Lyytinen, Heikki

AU - Schulte-Körne, Gert

AU - Nöthen, Markus M

AU - Leppänen, Paavo H T

AU - Peyrard-Janvid, Myriam

AU - Kere, Juha

PY - 2015/7

Y1 - 2015/7

N2 - Genetic studies of complex traits have become increasingly successful as progress is made in next-generation sequencing. We aimed at discovering single nucleotide variation present in known and new candidate genes for developmental dyslexia: CYP19A1, DCDC2, DIP2A, DYX1C1, GCFC2 (also known as C2orf3), KIAA0319, MRPL19, PCNT, PRMT2, ROBO1 and S100B. We used next-generation sequencing to identify single-nucleotide polymorphisms in the exons of these 11 genes in pools of 100 DNA samples of Finnish individuals with developmental dyslexia. Subsequent individual genotyping of those 100 individuals, and additional cases and controls from the Finnish and German populations, validated 92 out of 111 different single-nucleotide variants. A nonsynonymous polymorphism in DCDC2 (corrected P = 0.002) and a noncoding variant in S100B (corrected P = 0.016) showed a significant association with spelling performance in families of German origin. No significant association was found for the variants neither in the Finnish case-control sample set nor in the Finnish family sample set. Our findings further strengthen the role of DCDC2 and implicate S100B, in the biology of reading and spelling.

AB - Genetic studies of complex traits have become increasingly successful as progress is made in next-generation sequencing. We aimed at discovering single nucleotide variation present in known and new candidate genes for developmental dyslexia: CYP19A1, DCDC2, DIP2A, DYX1C1, GCFC2 (also known as C2orf3), KIAA0319, MRPL19, PCNT, PRMT2, ROBO1 and S100B. We used next-generation sequencing to identify single-nucleotide polymorphisms in the exons of these 11 genes in pools of 100 DNA samples of Finnish individuals with developmental dyslexia. Subsequent individual genotyping of those 100 individuals, and additional cases and controls from the Finnish and German populations, validated 92 out of 111 different single-nucleotide variants. A nonsynonymous polymorphism in DCDC2 (corrected P = 0.002) and a noncoding variant in S100B (corrected P = 0.016) showed a significant association with spelling performance in families of German origin. No significant association was found for the variants neither in the Finnish case-control sample set nor in the Finnish family sample set. Our findings further strengthen the role of DCDC2 and implicate S100B, in the biology of reading and spelling.

KW - Case-Control Studies

KW - Dyslexia

KW - Genetic Association Studies

KW - Genetic Predisposition to Disease

KW - Humans

KW - Microtubule-Associated Proteins

KW - Polymorphism, Single Nucleotide

KW - S100 Calcium Binding Protein beta Subunit

KW - Sequence Analysis, DNA

U2 - 10.1038/jhg.2015.37

DO - 10.1038/jhg.2015.37

M3 - Article

VL - 60

SP - 399

EP - 401

JO - Japanese Journal of Human Genetics

T2 - Japanese Journal of Human Genetics

JF - Japanese Journal of Human Genetics

SN - 1434-5161

IS - 7

ER -