Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The aim of this study was to determine whether total fertilization failure in human IVF can be partially explained by alterations in the gene that codes for protein C inhibitor. Forty-six men had IVF total fertilization failure and 51 controls with normal fertilization were screened for mutations in the protein C inhibitor gene by direct sequencing. The main finding was that in men involved in total fertilization failure, a heterozygous adenosine/guanine (A/G) base combination in position 1389 (rs2069990) (exon 6) in the protein C inhibitor gene was significantly more common compared with controls (10.9% vs. 0).

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Reproduktionsmedicin och gynekologi
Originalspråkengelska
Sidor (från-till)277-279
TidskriftFertility and Sterility
Volym93
Utgåva nummer1
StatusPublished - 2010
PublikationskategoriForskning
Peer review utfördJa