Power Cut: Inhibiting Mitochondrial Translation to Target Leukemia

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

In this issue of Cancer Cell, Skrtic et al. demonstrate that inhibition of mitochondrial ribosomes with tigecycline, a known antimicrobial, selectively kills leukemia cells. This finding highlights the metabolic susceptibility of leukemia cells to mitochondrial translational inhibition and identifies a compound with significant efficacy in an in vivo preclinical model.

Detaljer

Författare
Externa organisationer
  • Brigham and Women's Hospital / Harvard Medical School
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cell- och molekylärbiologi
Originalspråkengelska
Sidor (från-till)555-556
Antal sidor2
TidskriftCancer Cell
Volym20
Utgivningsnummer5
StatusPublished - 2011 nov 15
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa