Pre- and perinatal hypoxia associated with hippocampus/amygdala volume in bipolar disorder

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Pre- and perinatal hypoxia associated with hippocampus/amygdala volume in bipolar disorder. / Haukvik, U. K.; McNeil, Thomas; Lange, E. H.; Melle, I.; Dale, A. M.; Andreassen, O. A.; Agartz, I.

I: Psychological Medicine, Vol. 44, Nr. 5, 2014, s. 975-985.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Haukvik, UK, McNeil, T, Lange, EH, Melle, I, Dale, AM, Andreassen, OA & Agartz, I 2014, 'Pre- and perinatal hypoxia associated with hippocampus/amygdala volume in bipolar disorder', Psychological Medicine, vol. 44, nr. 5, s. 975-985. https://doi.org/10.1017/S0033291713001529

APA

Haukvik, U. K., McNeil, T., Lange, E. H., Melle, I., Dale, A. M., Andreassen, O. A., & Agartz, I. (2014). Pre- and perinatal hypoxia associated with hippocampus/amygdala volume in bipolar disorder. Psychological Medicine, 44(5), 975-985. https://doi.org/10.1017/S0033291713001529

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MLA

Vancouver

Author

Haukvik, U. K. ; McNeil, Thomas ; Lange, E. H. ; Melle, I. ; Dale, A. M. ; Andreassen, O. A. ; Agartz, I. / Pre- and perinatal hypoxia associated with hippocampus/amygdala volume in bipolar disorder. I: Psychological Medicine. 2014 ; Vol. 44, Nr. 5. s. 975-985.

RIS

TY - JOUR

T1 - Pre- and perinatal hypoxia associated with hippocampus/amygdala volume in bipolar disorder

AU - Haukvik, U. K.

AU - McNeil, Thomas

AU - Lange, E. H.

AU - Melle, I.

AU - Dale, A. M.

AU - Andreassen, O. A.

AU - Agartz, I.

PY - 2014

Y1 - 2014

N2 - Background Pre- and perinatal adversities may increase the risk for schizophrenia and bipolar disorder. Hypoxia-related obstetric complications (OCs) are associated with brain anatomical abnormalities in schizophrenia, but their association with brain anatomy variation in bipolar disorder is unknown. Method Magnetic resonance imaging brain scans, clinical examinations and data from the Medical Birth Registry of Norway were obtained for 219 adults, including 79 patients with a DSM-IV diagnosis of bipolar disorder (age 29.4 years, s.d.=11.8 years, 39% male) and 140 healthy controls (age 30.8 years, s.d.=12.0 years, 53% male). Severe hypoxia-related OCs throughout pregnancy/birth and perinatal asphyxia were each studied in relation to a priori selected brain volumes (hippocampus, lateral ventricles and amygdala, obtained with FreeSurfer), using linear regression models covarying for age, sex, medication use and intracranial volume. Multiple comparison adjustment was applied. Results Perinatal asphyxia was associated with smaller left amygdala volume (t=-2.59, p=0.012) in bipolar disorder patients, but not in healthy controls. Patients with psychotic bipolar disorder showed distinct associations between perinatal asphyxia and smaller left amygdala volume (t=-2.69, p=0.010), whereas patients with non-psychotic bipolar disorder showed smaller right hippocampal volumes related to both perinatal asphyxia (t=-2.60, p=0.015) and severe OCs (t=-3.25, p=0.003). No associations between asphyxia or severe OCs and the lateral ventricles were found. Conclusions Pre- and perinatal hypoxia-related OCs are related to brain morphometry in bipolar disorder in adulthood, with specific patterns in patients with psychotic versus non-psychotic illness.

AB - Background Pre- and perinatal adversities may increase the risk for schizophrenia and bipolar disorder. Hypoxia-related obstetric complications (OCs) are associated with brain anatomical abnormalities in schizophrenia, but their association with brain anatomy variation in bipolar disorder is unknown. Method Magnetic resonance imaging brain scans, clinical examinations and data from the Medical Birth Registry of Norway were obtained for 219 adults, including 79 patients with a DSM-IV diagnosis of bipolar disorder (age 29.4 years, s.d.=11.8 years, 39% male) and 140 healthy controls (age 30.8 years, s.d.=12.0 years, 53% male). Severe hypoxia-related OCs throughout pregnancy/birth and perinatal asphyxia were each studied in relation to a priori selected brain volumes (hippocampus, lateral ventricles and amygdala, obtained with FreeSurfer), using linear regression models covarying for age, sex, medication use and intracranial volume. Multiple comparison adjustment was applied. Results Perinatal asphyxia was associated with smaller left amygdala volume (t=-2.59, p=0.012) in bipolar disorder patients, but not in healthy controls. Patients with psychotic bipolar disorder showed distinct associations between perinatal asphyxia and smaller left amygdala volume (t=-2.69, p=0.010), whereas patients with non-psychotic bipolar disorder showed smaller right hippocampal volumes related to both perinatal asphyxia (t=-2.60, p=0.015) and severe OCs (t=-3.25, p=0.003). No associations between asphyxia or severe OCs and the lateral ventricles were found. Conclusions Pre- and perinatal hypoxia-related OCs are related to brain morphometry in bipolar disorder in adulthood, with specific patterns in patients with psychotic versus non-psychotic illness.

KW - MRI

KW - neurodevelopment

KW - neuroimaging

KW - obstetric complications

KW - psychosis

U2 - 10.1017/S0033291713001529

DO - 10.1017/S0033291713001529

M3 - Article

C2 - 23803260

VL - 44

SP - 975

EP - 985

JO - Psychological Medicine

JF - Psychological Medicine

SN - 1469-8978

IS - 5

ER -