Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Previous in vitro and case–control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre-diagnostic circulating IGF-I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre-diagnostic plasma concentrations of IGF-I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow-up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre-diagnostic circulating IGF-I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95% CI: 0.66–1.24, ptrend = 0.40) or UCC (n of cases = 776; 0.91, 0.65–1.26, ptrend = 0.40). There was no significant evidence of heterogeneity in the association of IGF-I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis (pheterogeneity > 0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF-I concentrations and bladder cancer risk.


  • Crystal Lin
  • Ruth C. Travis
  • Paul N. Appleby
  • Sarah Tipper
  • Elisabete Weiderpass
  • Jenny Chang-Claude
  • Inger T. Gram
  • Rudolf Kaaks
  • Lambertus A. Kiemeney
  • Börje Ljungberg
  • Rosario Tumino
  • Anne Tjønneland
  • Nina Roswall
  • Kim Overvad
  • Marie Christine Boutron-Ruault
  • Francesca Romana Manciniveri
  • Gianluca Severi
  • Antonia Trichopoulou
  • Giovanna Masala
  • Carlotta Sacerdote
  • Claudia Agnoli
  • Salvatore Panico
  • Bas Bueno-de-Mesquita
  • Petra H. Peeters
  • Elena Salamanca-Fernández
  • Maria Dolores Chirlaque
  • Eva Ardanaz
  • Miren Dorronsoro
  • Virginia Menéndez
  • Leila Luján-Barroso
  • Heinz Freisling
  • Marc Gunter
  • Dagfinn Aune
  • Amanda J. Cross
  • Elio Riboli
  • Timothy J. Key
  • Aurora Perez-Cornago
Enheter & grupper
Externa organisationer
  • University of Oxford
  • UiT The Arctic University of Norway, Tromsø
  • Cancer Registry of Norway Institute of Population-Based Cancer Research
  • Karolinska Institute
  • University of Helsinki
  • German Cancer Research Centre
  • Radboud University Nijmegen
  • Umeå University
  • Civic and M.P.Arezzo Hospital
  • Danish Cancer Society Research Center
  • Aarhus University
  • Versailles Saint-Quentin-en-Yvelines University
  • Stabilite genetique et oncogenese
  • Hellenic Health Foundation, Athens
  • Cancer Research and Prevention Institute
  • Citta' della Salute e della Scienza Hospital-University of Turin
  • Istituto Nazionale dei Tumori
  • University of Naples Federico II
  • National Institute for Public Health and the Environment (RIVM)
  • University Medical Center Utrecht
  • Imperial College London
  • University of Malaya
  • University of Granada
  • CIBER Epidemiology and Public Health (CIBERESP)
  • Murcia Regional Health Council
  • University of Murcia
  • Health Research Institute of Navarra (IDISNA)
  • Public Health Directorate
  • Bellvitge University Hospital-IDIBELL
  • University of Barcelona
  • Skåne University Hospital
  • International Agency for Research on Cancer, World Health Organization
  • Bjørknes University College
  • San Sebastian

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi


Sidor (från-till)2351-2358
Antal sidor8
TidskriftInternational Journal of Cancer
Utgåva nummer10
StatusPublished - 2018 nov 15
Peer review utfördJa