Prediction of disease-related mutations affecting protein localization.
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Eukaryotic cells contain numerous compartments, which have different protein constituents. Proteins are typically directed to compartments by short peptide sequences that act as targeting signals. Translocation to the proper compartment allows a protein to form the necessary interactions with its partners and take part in biological networks such as signalling and metabolic pathways. If a protein is not transported to the correct intracellular compartment either the reaction performed or information carried by the protein does not reach the proper site, causing either inactivation of central reactions or misregulation of signalling cascades, or the mislocalized active protein has harmful effects by acting in the wrong place.
Ämnesklassifikation (UKÄ) – OBLIGATORISK
|Status||Published - 2009|
|Peer review utförd||Ja|