Prediction of pre-eclampsia combining NGAL and other biochemical markers with Doppler in the first and/or second trimester of pregnancy: A pilot study

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Objective To determine the performance of maternal characteristics, Doppler and a set of biochemical markers for pre-eclampsia (PE) screening at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks’ gestation. Study design Prospectively enrolled women at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks. Maternal characteristics, uterine artery pulsatility index (UtA-PI), ductus venosus pulsatility index (DV-PI) and serum biomarkers including pregnancy associated plasma protein – A (PAPP-A), placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), s-Flt-1/PLGF ratio, asymmetric dimethylarginine (ADMA), matrix metalloproteinase 9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and MMP-9/NGAL complex were recorded. Results Combination of NGAL and BMI in a logistic regression model detected 70% of PE in the first trimester (p = 0.001). Including UtA-PI and DV-PI in the model sensitivity reached 77.8% with 96.6% specificity (p = 0.004). Combination of second trimester NGAL and s-Flt-1/PLGF ratio yield specificity 100% (p = 0.001). Combination of second trimester UtA-PI with first trimester NGAL, BMI and age detected 80% of PE with specificity 91.9% (p = 0.001). Conclusion Combination of NGAL, maternal characteristics and Doppler parameters in the first and/or second trimester can detect a consistent number of PE pregnancies. NGAL is a potent new biomarker for the prediction of preeclampsia.


  • Grigorios A. Karampas
  • Makarios I. Eleftheriades
  • Konstantinos C. Panoulis
  • Myrto D. Rizou
  • Alexander D. Haliassos
  • Dimitra K. Metallinou
  • George P. Mastorakos
  • Demetrios A. Rizos
Externa organisationer
  • Technological Educational Institute of Athens
  • Skåne University Hospital
  • National and Kapodistrian University of Athens
  • Diamedica - Diagnostiki Iatriki S.A.

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Reproduktionsmedicin och gynekologi


Sidor (från-till)153-157
Antal sidor5
TidskriftEuropean Journal of Obstetrics, Gynecology, and Reproductive Biology
StatusPublished - 2016 okt 1
Peer review utfördJa
Externt publiceradJa