Prenatal stress reduces SI00B in the neonatal rat hippocampus

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Prenatal stress has been shown to disturb neonatal rat brain development. The astroglial-specific neurotrophic factor S100B is known to play an important role in normal brain development. In the present study, we investigated the effects of prenatal stress on S100B concentrations in the hippocampus of I-day-old Fischer 344 rats. Overall, prenatal stress resulted in a 25% reduction in hippocampal S100B content. Further, male hippocampal S100B content was negatively correlated with plasma corticosterone levels. Positive correlations were found between female S100B levels and fetal growth, and hippocampal brain-derived neurotrophic factor content. In conclusion, the observed reduction in neonatal hippocampal S100B levels, as a consequence of prenatal stress, may be involved in affecting postnatal brain development.

Detaljer

Författare
  • Daniel L. A. Van den Hove
  • Harry W. M. Steinbusch
  • Matteo Bruschettini
  • Diego Gazzolo
  • Rosanna Frulio
  • Arjan Scheepens
  • Jos Prickaerts
  • Carlos E. Blanco
Externa organisationer
  • Maastricht University
  • University of Auckland
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi

Nyckelord

Originalspråkengelska
Sidor (från-till)1077-1080
TidskriftNeuroReport
Volym17
Utgåva nummer10
StatusPublished - 2006
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa