Preoperative fine needle aspiration from human breast cancer is a valuable sampling material for progesterone receptor and cytometric DNA analysis

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Bibtex

@article{8f8a9ffffdeb48ecb99ec7c194051868,
title = "Preoperative fine needle aspiration from human breast cancer is a valuable sampling material for progesterone receptor and cytometric DNA analysis",
abstract = "In a breast cancer series (n = 54), preoperative fine needle aspiration (FNA) was compared with biopsy at primary surgery as a source of material for the determination of progesterone receptor (PgR) content by enzyme immuno assay. The respective results manifested a strong correlation (r(s) = 0.82). The fact that PgR content was usually higher in FNA samples than in the corresponding biopsy samples and the finding that 11{\%} of the tumours were PgR positive in FNA but PgR negative in the corresponding biopsy samples suggest a greater proportion of malignant cells to be obtained with FNA than in surgical biopsy. In another breast cancer series (n = 50), corresponding comparisons for DNA flow cytometry showed concordance in ploidy status (diploid vs. non-diploid) in 84{\%} of cases and a strong correlation in S-phase fraction values (r(s) = 0.70). At DNA image cytometry, concordant results (Auer I + II vs. Auer III + IV) were obtained in 87{\%} of the cases. To sum up, FNA seems to be a useful sampling technique for PgR determination and DNA cytometry.",
author = "M{\aa}rten Fern{\"o} and Bo Baldetorp and Ghita Fallenius and Ingrid Idvall and Ulla Johansson and Dick Killander",
note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Oncology, MV (013035000), Pathology, (Lund) (013030000)",
year = "1996",
doi = "10.3109/02841869609098517",
language = "English",
volume = "35",
pages = "19--25",
journal = "Acta Oncologica",
issn = "1651-226X",
publisher = "Taylor & Francis",
number = "S8",

}