Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Introduction: Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology. Methods: We included 3451 Aβ+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE ε4 prevalence in relation to age, sex, education, and geographical location. Results: The APOE ε4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in Aβ+ cognitively normal and Aβ+ mild cognitive impairment (P <.05) but not in Aβ+ AD dementia (P =.66). The prevalence was highest in Northern Europe but did not vary by sex or education. Discussion: The APOE ε4 prevalence in AD was higher than that in previous studies, which did not require presence of Aβ pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location.

Detaljer

Författare
  • Colin Groot
  • Willemijn J. Jansen
  • Susan M. Landau
  • Victor L. Villemagne
  • Sebastiaan Engelborghs
  • Mark M. Mintun
  • Alberto Lleo
  • José Luis Molinuevo
  • William J. Jagust
  • Giovanni B. Frisoni
  • Adrian Ivanoiu
  • Gaël Chételat
  • Catarina Resende de Oliveira
  • Karen M. Rodrigue
  • Johannes Kornhuber
  • Anders Wallin
  • Aleksandra Klimkowicz-Mrowiec
  • Ramesh Kandimella
  • Julius Popp
  • Pauline P. Aalten
  • Dag Aarsland
  • Daniel Alcolea
  • Ina S. Almdahl
  • Inês Baldeiras
  • Mark A. van Buchem
  • Enrica Cavedo
  • Kewei Chen
  • Ann D. Cohen
  • Stefan Förster
  • Juan Fortea
  • Kristian S. Frederiksen
  • Yvonne Freund-Levi
  • Kiran Dip Gill
  • Olymbia Gkatzima
  • Timo Grimmer
  • Harald Hampel
  • Sanna Kaisa Herukka
  • Peter Johannsen
  • Koen van Laere
  • Mony J. de Leon
  • Wolfgang Maier
  • Jan Marcusson
  • Olga Meulenbroek
  • Hanne M. Møllergård
  • John C. Morris
  • Barbara Mroczko
  • Arto Nordlund
  • Sudesh Prabhakar
  • Oliver Peters
  • Lorena Rami
  • Eloy Rodríguez-Rodríguez
  • Catherine M. Roe
  • Eckart Rüther
  • Isabel Santana
  • Johannes Schröder
  • Sang W. Seo
  • Hilkka Soininen
  • Luiza Spiru
  • Hanne Struyfs
  • Charlotte E. Teunissen
  • Frans R.J. Verhey
  • Stephanie J.B. Vos
  • Linda J.C. van Waalwijk van Doorn
  • Gunhild Waldemar
  • Jens Wiltfang
  • Rik Vandenberghe
  • David J. Brooks
  • Tormod Fladby
  • Christopher C. Rowe
  • Alexander Drzezga
  • Marcel M. Verbeek
  • Marie Sarazin
  • David A. Wolk
  • Adam S. Fleisher
  • William E. Klunk
  • Duk L. Na
  • Pascual Sánchez-Juan
  • Dong Young Lee
  • Agneta Nordberg
  • Magda Tsolaki
  • Vincent Camus
  • Juha O. Rinne
  • Anne M. Fagan
  • Henrik Zetterberg
  • Kaj Blennow
  • Gil D. Rabinovici
  • Bart N.M. van Berckel
  • Wiesje M. van der Flier
  • Philip Scheltens
  • Pieter Jelle Visser
Enheter & grupper
Externa organisationer
  • Maastricht University
  • University of California, Berkeley
  • Austin Health
  • University of Antwerp
  • Avid Radiopharmaceuticals, Inc
  • Hospital de Sant Pau
  • Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)
  • Geneva University Hospital
  • Centro San Giovanni di Dio Fatebenefratelli
  • Saint-Luc University Hospital
  • University of Caen Normandy
  • University Hospital of Coimbra
  • Friedrich-Alexander University Erlangen-Nürnberg
  • Jagellonian University
  • Postgraduate Institute of Medical Education and Research
  • Lausanne University Hospital
  • Stavanger University Hospital
  • Akershus University Hospital
  • Leiden University Medical Centre
  • Banner Alzheimer's Institute
  • University of Pittsburgh
  • Technical University of Munich
  • University of Copenhagen
  • Karolinska University Hospital
  • Aristotle University of Thessaloniki
  • University of Eastern Finland
  • Copenhagen University Hospital
  • Catholic University of Leuven
  • New York University
  • University of Bonn
  • Linköping University
  • Radboud University Nijmegen
  • Washington University in St. Louis
  • Medical University of Bialystok
  • German Center for Neurodegenerative Diseases
  • University of Cantabria
  • University Medical Center Göttingen
  • Heidelberg University
  • Sungkyunkwan University
  • Carol Davila University of Medicine and Pharmacy
  • VU University Medical Center
  • Imperial College London
  • University of Cologne
  • Paris Descartes University
  • University of Pennsylvania
  • Lilly Research Laboratories
  • University of California, San Diego
  • Seoul National University
  • François Rabelais University
  • University College London
  • Göteborgs universitet
  • Sahlgrenska University Hospital
  • University of Texas Health Science Centre
  • University of Geneva
  • Université catholique de Louvain
  • University of Coimbra
  • University of Texas
  • Pitié-Salpêtrière University Hospital
  • Pierre and Marie Curie University
  • Karolinska Institute
  • Ludwig-Maximilian University of Munich
  • Kuopio University Hospital
  • University of Turku
  • Turku University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi

Nyckelord

Originalspråkengelska
Sidor (från-till)913-924
TidskriftAlzheimer's and Dementia
Volym14
Utgivningsnummer7
Tidigt onlinedatum2018 mar 28
StatusPublished - 2018 jul
PublikationskategoriForskning
Peer review utfördJa