Preventive and Therapeutic Effects of Phosphoinositide 3-Kinase Inhibitors on Acute Lung Injury

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

Preventive and Therapeutic Effects of Phosphoinositide 3-Kinase Inhibitors on Acute Lung Injury. / Chen, Chengshui; Fang, Xiaocong; Wang, Yaoli; Li, Yuping; Wang, Diane; Zhao, Xia; Bai, Chunxue; Wang, Xiangdong.

I: Chest, Vol. 140, Nr. 2, 2011, s. 391-400.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Chen, C, Fang, X, Wang, Y, Li, Y, Wang, D, Zhao, X, Bai, C & Wang, X 2011, 'Preventive and Therapeutic Effects of Phosphoinositide 3-Kinase Inhibitors on Acute Lung Injury', Chest, vol. 140, nr. 2, s. 391-400. https://doi.org/10.1378/chest.10-3060

APA

Chen, C., Fang, X., Wang, Y., Li, Y., Wang, D., Zhao, X., Bai, C., & Wang, X. (2011). Preventive and Therapeutic Effects of Phosphoinositide 3-Kinase Inhibitors on Acute Lung Injury. Chest, 140(2), 391-400. https://doi.org/10.1378/chest.10-3060

CBE

MLA

Vancouver

Author

Chen, Chengshui ; Fang, Xiaocong ; Wang, Yaoli ; Li, Yuping ; Wang, Diane ; Zhao, Xia ; Bai, Chunxue ; Wang, Xiangdong. / Preventive and Therapeutic Effects of Phosphoinositide 3-Kinase Inhibitors on Acute Lung Injury. I: Chest. 2011 ; Vol. 140, Nr. 2. s. 391-400.

RIS

TY - JOUR

T1 - Preventive and Therapeutic Effects of Phosphoinositide 3-Kinase Inhibitors on Acute Lung Injury

AU - Chen, Chengshui

AU - Fang, Xiaocong

AU - Wang, Yaoli

AU - Li, Yuping

AU - Wang, Diane

AU - Zhao, Xia

AU - Bai, Chunxue

AU - Wang, Xiangdong

PY - 2011

Y1 - 2011

N2 - Background: Phosphoinositide 3-kinases (PI3Ks) are involved in a number of biologic responses. Recent preclinical studies demonstrated that the PI3K-dominant signal pathway could play an important role in the development of acute lung injury, although the mechanism remains unclear. Methods: CD-1 mice were administered different PI3K inhibitors either intranasally or intragastrically once a day for 3 days before intratracheal instillation of lipopolysaccharide at 4 h and 24 h. Effects of SHBM1009 on lipopolysaccharide-induced capillary permeability, leukocyte distribution and activation, and epithelial cell function were measured. Therapeutic effects of SHBM1009 on pancreatic elastase-induced lung injury were evaluated in rats. Results: The data demonstrated that the local delivery of PI3K inhibitors played more effective roles in the prevention of endotoxin-induced lung injury than the systemic delivery. The preventive effects of PI3K inhibitors varied most likely because of chemical properties, targeting sites, and pharmacokinetics. The local PI3K inhibitors prevented both endotoxin- and elastase-induced lung injury in mice and rats, possibly through directly inhibiting or inactivating the function of airway epithelial cells, which could not produce chemoattractant factors to activate neutrophils and macrophages. Conclusions: PI3K may be a therapeutic target for lung injury, and local delivery of PI3K inhibitors may be one of the optimal approaches for the therapy. CHEST 2011; 140(2):391-400

AB - Background: Phosphoinositide 3-kinases (PI3Ks) are involved in a number of biologic responses. Recent preclinical studies demonstrated that the PI3K-dominant signal pathway could play an important role in the development of acute lung injury, although the mechanism remains unclear. Methods: CD-1 mice were administered different PI3K inhibitors either intranasally or intragastrically once a day for 3 days before intratracheal instillation of lipopolysaccharide at 4 h and 24 h. Effects of SHBM1009 on lipopolysaccharide-induced capillary permeability, leukocyte distribution and activation, and epithelial cell function were measured. Therapeutic effects of SHBM1009 on pancreatic elastase-induced lung injury were evaluated in rats. Results: The data demonstrated that the local delivery of PI3K inhibitors played more effective roles in the prevention of endotoxin-induced lung injury than the systemic delivery. The preventive effects of PI3K inhibitors varied most likely because of chemical properties, targeting sites, and pharmacokinetics. The local PI3K inhibitors prevented both endotoxin- and elastase-induced lung injury in mice and rats, possibly through directly inhibiting or inactivating the function of airway epithelial cells, which could not produce chemoattractant factors to activate neutrophils and macrophages. Conclusions: PI3K may be a therapeutic target for lung injury, and local delivery of PI3K inhibitors may be one of the optimal approaches for the therapy. CHEST 2011; 140(2):391-400

U2 - 10.1378/chest.10-3060

DO - 10.1378/chest.10-3060

M3 - Article

C2 - 21636664

VL - 140

SP - 391

EP - 400

JO - Chest

JF - Chest

SN - 1931-3543

IS - 2

ER -