Primary treatment patterns and survival of cervical cancer in Sweden: A population-based Swedish Gynecologic Cancer Group Study

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Objective: Survival in cervical cancer has improved little over the last decades. We aimed to elucidate primary treatment patterns and survival. Methods: Population-based study of patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed 2011–2015. Main outcome was 5-year relative survival (RS). Age-standardised RS (AS-RS) was estimated for the total cohort and for the pooled study population of squamous, adenosquamous-, adenocarcinoma. Results: Median follow-up time was 4.6 years. The study population consisted of 2141 patients; 97% of the 2212 patients in the total cohort and the 5-year AS-RS was 71% and 70%, respectively. RS stage IB1: surgery alone 95% vs. 72% for definitive chemoradiotherapy (CT-RT) (p < 0.001). In stage IIA1 74% had CT-RT, and 47% of operated patients received adjuvant (CT)-RT. RS stage IB2: surgically treated 81% (69% received adjuvant (CT)-RT) vs. 76% for (CT)-RT (p = 0.73). RS stage IIB: 77% for CT-RT + brachytherapy (BT), 37% for RT + BT (p = 0.045) and 27% for RT-BT (p < 0.001). Stages III-IVA; <40% received CT-RT + BT, RS 45% vs. 18% for RT-BT (RR 4.1, p < 0.001). RS stage IVB 7%. Conclusion: Primary treatment of cervical cancer in Sweden adhered to evidence-based standard of care. Areas of improvement include optimising treatment for stages III-IVA, and avoiding combining surgery and radiotherapy.

Detaljer

Författare
  • Maria Bjurberg
  • Erik Holmberg
  • Christer Borgfeldt
  • Angelique Flöter-Rådestad
  • Pernilla Dahm-Kähler
  • Elisabet Hjerpe
  • Thomas Högberg
  • Preben Kjølhede
  • Janusz Marcickiewicz
  • Per Rosenberg
  • Karin Stålberg
  • Bengt Tholander
  • Kristina Hellman
  • Elisabeth Åvall-Lundqvist
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
  • Sahlgrenska Academy
  • Karolinska University Hospital
  • Sahlgrenska University Hospital
  • Linköping University
  • Uppsala universitet, Historiska institutionen
  • Uppsala University Hospital
  • Visby hospital
  • Hallands sjukhus, Varberg
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi

Nyckelord

Originalspråkengelska
TidskriftGynecologic Oncology
StatusE-pub ahead of print - 2019
PublikationskategoriForskning
Peer review utfördJa