Prion-like transmission of protein aggregates in neurodegenerative diseases.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Neurodegenerative diseases are commonly associated with the accumulation of intracellular or extracellular protein aggregates. Recent studies suggest that these aggregates are capable of crossing cellular membranes and can directly contribute to the propagation of neurodegenerative disease pathogenesis. We propose that, once initiated, neuropathological changes might spread in a 'prion-like' manner and that disease progression is associated with the intercellular transfer of pathogenic proteins. The transfer of naked infectious particles between cells could therefore be a target for new disease-modifying therapies.

Detaljer

Författare
  • Patrik Brundin
  • Ronald Melki
  • Ron Kopito
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper
Originalspråkengelska
Sidor (från-till)301-307
TidskriftNature Reviews. Molecular Cell Biology
Volym11
Utgåva nummer4
StatusPublished - 2010
PublikationskategoriForskning
Peer review utfördJa