Prognostic importance of new small Q waves following non-ST-elevation acute coronary syndromes

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Prognostic importance of new small Q waves following non-ST-elevation acute coronary syndromes. / Alexander, JH; Harrington, RA; Bhapkar, M; Mahaffey, KW; Lincoff, AM; Ohman, EM; Klootwijk, P; Pahlm, Olle; Henden, B; Deckers, JW; Simoons, ML; Califf, RM; Wagner, GS.

I: American Journal of Medicine, Vol. 115, Nr. 8, 2003, s. 613-619.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Alexander, JH, Harrington, RA, Bhapkar, M, Mahaffey, KW, Lincoff, AM, Ohman, EM, Klootwijk, P, Pahlm, O, Henden, B, Deckers, JW, Simoons, ML, Califf, RM & Wagner, GS 2003, 'Prognostic importance of new small Q waves following non-ST-elevation acute coronary syndromes', American Journal of Medicine, vol. 115, nr. 8, s. 613-619. https://doi.org/10.1016/j.amjmed.2003.08.007

APA

Alexander, JH., Harrington, RA., Bhapkar, M., Mahaffey, KW., Lincoff, AM., Ohman, EM., Klootwijk, P., Pahlm, O., Henden, B., Deckers, JW., Simoons, ML., Califf, RM., & Wagner, GS. (2003). Prognostic importance of new small Q waves following non-ST-elevation acute coronary syndromes. American Journal of Medicine, 115(8), 613-619. https://doi.org/10.1016/j.amjmed.2003.08.007

CBE

Alexander JH, Harrington RA, Bhapkar M, Mahaffey KW, Lincoff AM, Ohman EM, Klootwijk P, Pahlm O, Henden B, Deckers JW, Simoons ML, Califf RM, Wagner GS. 2003. Prognostic importance of new small Q waves following non-ST-elevation acute coronary syndromes. American Journal of Medicine. 115(8):613-619. https://doi.org/10.1016/j.amjmed.2003.08.007

MLA

Vancouver

Author

Alexander, JH ; Harrington, RA ; Bhapkar, M ; Mahaffey, KW ; Lincoff, AM ; Ohman, EM ; Klootwijk, P ; Pahlm, Olle ; Henden, B ; Deckers, JW ; Simoons, ML ; Califf, RM ; Wagner, GS. / Prognostic importance of new small Q waves following non-ST-elevation acute coronary syndromes. I: American Journal of Medicine. 2003 ; Vol. 115, Nr. 8. s. 613-619.

RIS

TY - JOUR

T1 - Prognostic importance of new small Q waves following non-ST-elevation acute coronary syndromes

AU - Alexander, JH

AU - Harrington, RA

AU - Bhapkar, M

AU - Mahaffey, KW

AU - Lincoff, AM

AU - Ohman, EM

AU - Klootwijk, P

AU - Pahlm, Olle

AU - Henden, B

AU - Deckers, JW

AU - Simoons, ML

AU - Califf, RM

AU - Wagner, GS

PY - 2003

Y1 - 2003

N2 - PURPOSE: to investigate the prognostic importance of new small Q waves following an acute coronary syndrome. METHODS: We assessed 6-month mortality in 10,501 patients with non-ST-elevation acute coronary syndromes who had survived 30 days and had both admission and 30-day electrocardiograms. Patients were stratified by whether they had no new Q waves (n = 9447), new 30- to 40-ms Q waves (n = 733), or new greater than or equal to40-ms Q waves (n = 321). RESULTS: Mortality was higher in patients with 30- to 40-ms Q waves than in those with no new Q waves (3.4% [25/733] vs. 2.4% [227/9447], P = 0.005), and even higher in those with greater than or equal to40-ms Q waves (5.3% [17/321], P = 0.002). After adjustment for baseline risk predictors, mortality remained higher in patients with new 30- to 40-ms Q waves (odds ratio [OR] = 1.30; 95% confidence interval [CI]: 0.85 to 1.98; P = 0.23) and those with new greater than or equal to40-ms Q waves (OR = 1.87; 95% Cl: 1.13 to 3.09; P = 0.01). CONCLUSION: Patients with new small Q waves following a non-ST-elevation acute coronary syndrome are at increased risk of adverse outcomes. These small Q waves should be considered diagnostic of myocardial infarction. Further research should investigate whether even smaller QRS changes are prognostically important. (C)2003 by Excerpta Medica Inc.

AB - PURPOSE: to investigate the prognostic importance of new small Q waves following an acute coronary syndrome. METHODS: We assessed 6-month mortality in 10,501 patients with non-ST-elevation acute coronary syndromes who had survived 30 days and had both admission and 30-day electrocardiograms. Patients were stratified by whether they had no new Q waves (n = 9447), new 30- to 40-ms Q waves (n = 733), or new greater than or equal to40-ms Q waves (n = 321). RESULTS: Mortality was higher in patients with 30- to 40-ms Q waves than in those with no new Q waves (3.4% [25/733] vs. 2.4% [227/9447], P = 0.005), and even higher in those with greater than or equal to40-ms Q waves (5.3% [17/321], P = 0.002). After adjustment for baseline risk predictors, mortality remained higher in patients with new 30- to 40-ms Q waves (odds ratio [OR] = 1.30; 95% confidence interval [CI]: 0.85 to 1.98; P = 0.23) and those with new greater than or equal to40-ms Q waves (OR = 1.87; 95% Cl: 1.13 to 3.09; P = 0.01). CONCLUSION: Patients with new small Q waves following a non-ST-elevation acute coronary syndrome are at increased risk of adverse outcomes. These small Q waves should be considered diagnostic of myocardial infarction. Further research should investigate whether even smaller QRS changes are prognostically important. (C)2003 by Excerpta Medica Inc.

U2 - 10.1016/j.amjmed.2003.08.007

DO - 10.1016/j.amjmed.2003.08.007

M3 - Article

VL - 115

SP - 613

EP - 619

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 8

ER -