Progress update from the hippocampal subfields group

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Progress update from the hippocampal subfields group. / Hippocampal Subfields Group; Olsen, Rosanna K. ; Berron, David; Wisse, Laura E.M. .

I: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 11, 2019, s. 439-449.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Hippocampal Subfields Group ; Olsen, Rosanna K. ; Berron, David ; Wisse, Laura E.M. . / Progress update from the hippocampal subfields group. I: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2019 ; Vol. 11. s. 439-449.

RIS

TY - JOUR

T1 - Progress update from the hippocampal subfields group

AU - Hippocampal Subfields Group

AU - Olsen, Rosanna K.

AU - Berron, David

AU - Wisse, Laura E.M.

PY - 2019

Y1 - 2019

N2 - Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide. © 2019 The Authors

AB - Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide. © 2019 The Authors

KW - Cytoarchitecture

KW - ex vivo

KW - Hippocampus

KW - Histology

KW - Human

KW - Neuroanatomy

KW - Neuroimaging

KW - Structural imaging

KW - Volumetry

U2 - 10.1016/j.dadm.2019.04.001

DO - 10.1016/j.dadm.2019.04.001

M3 - Article

VL - 11

SP - 439

EP - 449

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

T2 - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

SN - 2352-8729

ER -