Proliferation and benevolence—A framework for dissecting the mechanisms of microbial virulence and health promotion

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Key topics in the study of host–microbe interactions—such as the prevention of drug resistance and the exploitation of beneficial effects of bacteria—would benefit from concerted efforts with both mechanistic and evolutionary approaches. But due to differences in intellectual traditions, insights gained in one field rarely benefit the other. Here, we develop a conceptual and analytical framework for the integrated study of host–microbe interactions. This framework partitions the health effects of microbes and the effector molecules they produce into components with different evolutionary implications. It thereby facilitates the prediction of evolutionary responses to inhibition and exploitation of specific molecular mechanisms.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Georgia Institute of Technology
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Farmaceutisk vetenskap
  • Bioinformatik och systembiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)879-888
Antal sidor10
TidskriftEvolutionary Applications
Volym13
Utgåva nummer5
Tidigt onlinedatum2020 mar 14
StatusPublished - 2020 maj
PublikationskategoriForskning
Peer review utfördJa